Evidence map›Paper›PMID 42581114›Full record

ReviewNPJ cardiovascular health2026

Periodontal disease and cardiovascular events: mechanisms, biomarkers, and clinical translation.

Teng Qi, Ting-Xuan Huang, Jin-Suo Xiao, Zhen-Tao Zhu, Si-Yu Ren, Pei-Lin Xie, Ling-Jun Yao

Abstract readReview
In one paragraph

Review in NPJ cardiovascular health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Teng QiSchool of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, Guangdong, China.
Ting-Xuan HuangSchool of Medicine, Northwest University, Xi'an, Shaanxi, China.
Jin-Suo XiaoSchool of Medicine, Northwest University, Xi'an, Shaanxi, China.
Zhen-Tao ZhuSchool of Medicine, Northwest University, Xi'an, Shaanxi, China.
Si-Yu RenHospital of Stomatology, Wuhan University, WuHan, China.
Pei-Lin XieSchool of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Shenzhen, Guangdong, China. peilinxie@link.cuhk.edu.cn.
Ling-Jun YaoSchool of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, Guangdong, China. 225050029@link.cuhk.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review integrates epidemiological, mechanistic and clinical evidence demonstrating that patients with periodontitis carry higher risks of cardiovascular events than healthy individuals. Literature from major databases was analyzed narratively. Findings indicate higher risks of myocardial infarction, stroke, and atrial fibrillation driven by systemic inflammation, endothelial dysfunction, vascular invasion, oral-gut-vascular, and epigenetic pathways. Biomarkers show diagnostic potential, while therapy improves surrogate outcomes but not hard endpoints. The review integrates evidence to inform risk stratification and prevention strategies.

Identifiers

PMID42581114
PMCPMC13463043

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.