Evidence mapPaperPMID 42581297Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026

A collaborative framework for uncovering molecular and cellular drivers of VCID: Foundations for future interventions in dementia.

M Luisa Iruela-Arispe, Jason D Hinman, Andrew C Yang, Fabrice Dabertrand, Jin-Moo Lee, Gareth R Howell, VCID Centers without Walls Network

Abstract readReview
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M Luisa Iruela-ArispeNorthwestern CWOW. Northwestern University, Chicago, Illinois, USA.
Jason D HinmanUCLA VIBRANT CWOW. University of California, Los Angeles, California, USA.
Andrew C YangThe Gladstone/UCSF/UCI/Rush CWOW. Gladstone Institutes, San Francisco, California, USA.
Fabrice DabertrandThe Colorado Neurovascular Energetics CWOW, University of Colorado Anschutz, Aurora, Colorado, USA.
Jin-Moo LeeThe WashU UNWIND CWOW, Washington University, St Louis, Illinois, USA.
Gareth R HowellRush University, Chicago, Illinois, USA.
VCID Centers without Walls NetworkNorthwestern CWOW. Northwestern University, Chicago, Illinois, USA.

Funding

JAX/Emory/Columbia/Rush MINT-VCID CWOW NS139948NINDS NIH HHS RF1 NS139948NINDS NIH HHS RF1 NS139949NINDS NIH HHS RF1 NS139970NINDS NIH HHS RF1 NS139972NINDS NIH HHS RF1 NS139975NINDS NIH HHS RF1 NS140137Northwestern CWOW NS139949The Colorado Neurovascular Energetics CWOW NS140137The Gladstone/UCSF/UCI/Rush CWOW NS139975The WashU UNWIND CWOW NS139970UCLA VIBRANT CWOW NS139972
6 · The paper itself

Abstract

Vascular-related factors are now considered major contributors to most forms of dementia, including Alzheimer's disease. However, the degree to which vascular deficits contribute to risk, onset, and progression of cognitive impairment and dementia has only recently been appreciated. Our understanding of the mechanisms by which vascular deficits drive cognitive decline in dementia is still limited. Further, the testing of therapeutic approaches to prevent vascular deficits to treat dementia are few. These factors motivated the establishment of the Vascular Contributions to Cognitive Impairment and Dementia (VCID) Center Without Walls (CWOW) network, comprising institutes across the United States. We describe the current gaps and opportunities, and how, in collaboration with other relevant groups, the VCID CWOW network is aiming to tackle the major unmet need of developing improved therapeutic approaches targeting vascular deficits to treat dementia.

Indexed as

Cognitive DysfunctionDementiaDementia, VascularAnimalsHumansAlzheimer's diseasebiomarkersblood–brain barrierdementiaglial cellshuman diseaseimagingmolecular profilingmouse modelsvascular cellsVascular contributions

Identifiers

PMID42581297
PMCPMC13461783

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.