ArticleAdvanced healthcare materials2026
Amelioration of Cisplatin Nephrotoxicity by Fe-Pt Coordination Exchange-Triggered Ferroptosis Suppression.
Tiantian Chen, Panyu Du, Yuning Liu, Xuefei Chen, Zheng Wang, Xin Li, Xiujie Zhao, Yanjun Zhao
Abstract read
In one paragraphArticle in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Tiantian ChenSchool of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, Faculty of Medicine, Tianjin University, Tianjin, China.
Panyu DuSchool of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, Faculty of Medicine, Tianjin University, Tianjin, China.
Yuning LiuSchool of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, Faculty of Medicine, Tianjin University, Tianjin, China.
Xuefei ChenSchool of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, Faculty of Medicine, Tianjin University, Tianjin, China.
Zheng WangSchool of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, Faculty of Medicine, Tianjin University, Tianjin, China.
Xin LiSchool of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, Faculty of Medicine, Tianjin University, Tianjin, China.ORCID https://orcid.org/0000-0001-6044-6782 Xiujie ZhaoSchool of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, Faculty of Medicine, Tianjin University, Tianjin, China.ORCID https://orcid.org/0000-0001-9267-0252 Yanjun ZhaoSchool of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, Faculty of Medicine, Tianjin University, Tianjin, China.ORCID https://orcid.org/0000-0001-5739-1960 Funding
National Natural Science Foundation of China 22175130Tianjin Natural Science Foundation 24JCQNJC01740
6 · The paper itselfAbstract
Ferroptosis is an iron-dependent form of regulated cell death that has emerged as one of the mechanisms underlying cisplatin-induced nephrotoxicity. Here, we report an iron-chelating polymeric micelle for controlled cisplatin activation and ferroptosis suppression to address the above issue. The block copolymer, methoxyl polyethylene glycol-poly(glutamic acid) (mPEG-PGlu) was coupled with an iron chelator, deferiprone (Dfp) to generate the tailored amphiphilic conjugate, mPEG-P(Glu-Dfp) that could coordinate with activated cisplatin and self-assemble into micelles (Pt@M
Indexed as
CisplatinFerroptosisIronPlatinumAnimalsCell Line, TumorDeferiproneFemaleHumansIron Chelating AgentsKidneyMiceMice, Inbred BALB CMicellesPolyethylene GlycolsPolyglutamic AcidCisplatinDeferiproneIronIron Chelating AgentsMicellesmonomethoxypolyethylene glycolPlatinumPolyethylene GlycolsPolyglutamic Acidcisplatin nephrotoxicitycontrolled releasedrug deliveryferroptosismicelles
Identifiers
PMID42581566
PMCPMC13569017
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