ArticleThe journal of gene medicine2026
PCAT6 Regulates IGF2BP1/PD-L1 to Promote Immune Escape in Breast Cancer.
Article in The journal of gene medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aims to elucidate the mechanism through which prostate cancer-associated transcript 6 (PCAT6) modulates immune escape in triple-negative breast cancer (TNBC), focusing on its interaction with IGF2BP1 and PD-L1.
methodsWe analyzed 68 paired TNBC clinical specimens and utilized TNBC cells (BT-549, MDA-MB-468) with lentivirus-mediated gene manipulation. Functional assays included cell counting kit-8, EdU incorporation, Transwell migration/invasion, and co-culture with activated CD8
resultsPCAT6 was markedly upregulated in TNBC tissues and cell lines, correlating with advanced tumor stage and lymph node metastasis. PCAT6 knockdown restrained tumor cell proliferation, migration, and invasion while downregulating PD-L1 expression. In co-culture systems, PCAT6 depletion enhanced CD8
conclusionPCAT6 facilitates TNBC immune escape by enhancing PD-L1 mRNA stability through IGF2BP1, identifying the PCAT6/IGF2BP1/PD-L1 axis as a potential therapeutic target for breast cancer immunotherapy.
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