ArticleFrontiers in bioengineering and biotechnology2026
Investigating silver- and gold-functionalized electrospun PHBV fibers as dual-action antimicrobial and immunomodulatory biomaterials.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The growing prevalence of antibiotic-resistant bacteria highlights the urgent need for innovative antimicrobial materials. In this work, electrospun poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) fibers were functionalized with silver and gold nanoparticles (NPs) to combine high biocompatibility with strong antimicrobial activity. Methods: Silver and gold NPs were synthesized and characterized, confirming their anisotropic structure and high stability. Electrospinning produced uniform PHBV fibers, and surface modification with NPs via chitosan layer-by-layer ensured stable adhesion. Results: Antibacterial tests demonstrated that, among all, silver-containing samples exhibited complete inhibition of both Discussion: The developed PHBV-based fibers functionalized with metallic NPs demonstrated an excellent balance of safety, cytocompatibility, and antibacterial performance, making them promising candidates for biomedical applications that require both inflammation control and antimicrobial protection.
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