Evidence mapPaperPMID 42582447Full record

ReviewOncology reviews2026

Advancing the frontiers of ovarian cancer therapy: a comprehensive synthesis of emerging cell death paradigms.

Xi Ye, Weiping Zhu, Xiaojie Sun, Fangqiumei Yu, Qinhong Shen, Yingao Zheng, Xuanxuan Hong, Le Yu, Hanwen Zhang, Xiangfeng Zhang and 1 more

Abstract readReview
In one paragraph

Review in Oncology reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xi YeQinghai University Affiliated Clinical Medical College, Xining, Qinghai, China.
Weiping ZhuHefei Maternal and Child Health Hospital, Hefei, Anhui, China.
Xiaojie SunHebei Children's Hospital, Shijiazhuang, Hebei, China.
Fangqiumei YuQingdao Ruiside Hospital, Qingdao, Shandong, China.
Qinhong ShenShanghai Hospital of Traditional Chinese Medicine, Shanghai, China.
Yingao ZhengHefei Maternal and Child Health Hospital, Hefei, Anhui, China.
Xuanxuan HongQinghai University Affiliated Clinical Medical College, Xining, Qinghai, China.
Le YuAnhui Provincial Second People's Hospital, Hefei, Anhui, China.
Hanwen ZhangQinghai University Affiliated Clinical Medical College, Xining, Qinghai, China.
Xiangfeng ZhangHefei Eighth People's Hospital, Hefei, Anhui, China.
Liehong WangQinghai Red Cross Hospital, Xining, Qinghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer is one of the most lethal malignancies of the female reproductive system, largely because many patients are diagnosed at an advanced stage and eventually develop recurrent or treatment-resistant disease. Although cytoreductive surgery, platinum-based chemotherapy, PARP inhibitors, anti-angiogenic agents, and immunotherapy have improved management for selected patients, relapse and drug resistance remain major clinical barriers. Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, disulfidptosis, and autophagy-dependent cell death, are increasingly recognized as contributors to ovarian cancer progression, immune regulation, and therapeutic response. This review summarizes current evidence on these pathways in ovarian cancer, with emphasis on key regulators, mechanistic links to treatment resistance, potential biomarkers, and the limitations that currently restrict clinical translation.

Indexed as

cell deathdevelopment mechanismovarian cancerregulatory mechanismtherapeutic target

Identifiers

PMID42582447
PMCPMC13457741

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.