Evidence map›Paper›PMID 42582577›Full record

ArticleNeurotrauma reports

Natural History and Clinical Associations of Plasma Interleukin-6 Levels in Traumatic Brain Injury.

Leo Layzell, Eleftheria Kodosaki, Xiaoying Sun, Sonia Jain, Amanda Heslegrave, Eyal Soreq, Giovanni Nattino, Elena Garbero, Karl A Zimmerman, Neil S N Graham and 14 more

Abstract read
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In one paragraph

Article in Neurotrauma reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Leo LayzellDepartment of Brain Sciences, Imperial College London, London, UK.
Eleftheria KodosakiUK Dementia Research Institute at University College London, London, UK.
Xiaoying SunBiostatistics Research Center, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.
Sonia JainBiostatistics Research Center, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.
Amanda HeslegraveUK Dementia Research Institute at University College London, London, UK.
Eyal SoreqDepartment of Brain Sciences, Imperial College London, London, UK.
Giovanni NattinoIRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.ORCID https://orcid.org/0000-0002-3034-6251
Elena GarberoIRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Karl A ZimmermanDepartment of Brain Sciences, Imperial College London, London, UK.
Neil S N GrahamDepartment of Brain Sciences, Imperial College London, London, UK.
Federico MoroIRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Deborah NovelliIRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Primož GradišekFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Sandra MagnoniDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Henrik ZetterbergUK Dementia Research Institute at University College London, London, UK.
Kevin W WangDepartment of Neurobiology, Center for Neurotrauma, Multiomics & Biomarkers Morehouse School of Medicine, Atlanta, Georgia, USA.
Firas H KobeissyDepartment of Neurobiology, Center for Neurotrauma, Multiomics & Biomarkers Morehouse School of Medicine, Atlanta, Georgia, USA.
John K YueDepartment of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-9694-7722
Ava M PuccioDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Guido BertoliniIRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Ramon Diaz-ArrastiaPerelman School of Medicine, University of Pennsylvania, Pittsburgh, Pennsylvania, USA.
Geoffrey T ManleyDepartment of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
David J SharpDepartment of Brain Sciences, Imperial College London, London, UK.
Lucia M LiDepartment of Brain Sciences, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-7339-4854

Funding

Transforming Research and Clinical Knowledge in Traumatic Brain InjuryU01NS086090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ-ARRASTIA, RAMON, GIACINO, JOSEPH THOMAS · 2013 to 2017
$19.1M
NINDS NIH HHS U01 NS086090
6 · The paper itself

Abstract

Inflammation following traumatic brain injury (TBI) may contribute to long-term morbidity. We aimed to characterize plasma interleukin-6 (IL6) trajectory after TBI and assess associations with imaging, biomarkers, and outcomes. Secondary analysis of three prospective multicenter observational cohorts: BIO-AX-TBI (United Kingdom/Europe), CREACTIVE (Europe), and TRACK-TBI (United States). Adults (≥18 years) with TBI were enrolled at trauma centers, with non-TBI trauma (NTT) and non-injured controls (CON) included in BIO-AX-TBI and TRACK-TBI. Blood was obtained at acute (≤10 days), subacute (10 days-6 weeks), and chronic (6 and 12 months) timepoints. IL6 was measured on OLINK® (BIO-AX-TBI, CREACTIVE) or MSD S-PLEX (TRACK-TBI) platforms. The Glasgow Outcome Scale-Extended (GOS-E) assessed functional outcome at chronic time points, dichotomized as unfavorable (1-4) versus favorable (5-8). Additional outcomes included neuropsychiatric symptom scores, magnetic resonance imaging (MRI) measures (lesion volume, fractional anisotropy [FA]), and neuronal/astroglial injury markers. BIO-AX-TBI included

Indexed as

adult brain injuryIL6interleukin 6

Identifiers

PMID42582577
PMCPMC13458319

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.