ArticleNutrition research and practice2026
Treatment with saponins from
Article in Nutrition research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
BACKGROUND/
objectivesChronic high-fat diet (HFD) consumption induces low-grade intestinal inflammation. Although saponins from MATERIALS/
methodsHFD-fed mice were administered high-dose SPJs extract. The jejunal triglyceride (TG) levels, gene expression related to TG synthesis (glycerol-3-phosphate acyltransferase 3 [Gpat3] and diacylglycerol O-acyltransferase 2 [Dgat2]) and lipolysis (adipose triglyceride lipase [Atgl]), cytosolic lipid droplets (CLDs) deposition, ERS markers, and inflammatory responses were assessed.
resultsHFD feeding induced TG accumulation, upregulated Gpat3 and Dgat2, downregulated Atgl, and promoted CLDs deposition in jejunal epithelial cells. High-dose SPJs attenuated these changes. Furthermore, SPJs suppressed HFD-induced ERS and inflammation in the jejunum. In particular, short-term HFD exposure initially enhanced the antioxidant responses without significant ERS activation.
conclusionSPJs ameliorate HFD-induced jejunal inflammation by modulating lipid metabolic genes, reducing intracellular lipid accumulation, and alleviating ERS. These findings highlight the role of lipid-driven ERS in gut inflammation and the potential of SPJs as a therapeutic intervention.
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