ArticleJournal of cardiology cases2026
5-Fluorouracil-associated coronary vasospasm with takotsubo-like myocardial dysfunction: A case report.
Article in Journal of cardiology cases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Fluorouracil (5-FU) is frequently used in chemotherapy for several cancers, but adverse effects such as electrocardiography (ECG) ST-T changes and vascular spasms have been reported. Here, we present a case in which 5-FU triggered coronary vasospastic angina and takotsubo syndrome. A 65-year-old woman was admitted to our hospital for treatment of esophageal adenocarcinoma and initiated on 5-FU, leucovorin, and oxaliplatin. Three days after administration, she experienced chest pain that resolved spontaneously. On the fifth day, she was referred to our department. ECG showed ST-segment elevation in leads II, III, and aV Learning objective: 5-Fluorouracil (5-FU) is commonly used for various cancers. 5-FU has been reported to cause side effects such as chest pain, changes in the electrocardiogram, and coronary spastic angina. We experienced vasospastic coronary angina and takotsubo syndrome induced by 5-FU. The mechanism of takotsubo syndrome may be related to ischemia caused by coronary spasm.
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