Evidence map›Paper›PMID 42582884›Full record

ArticleJournal of inflammation research2026

Prognostic Significance of Complete Blood Counts-Derived Inflammatory Markers in Compensated Hepatocellular Carcinoma.

Ning Yang, Lei Zhang, Shiyu Liu, Zhentao Li, Xin Yang, Chuannan Wu, Tao Li, Hu Chen, Yongheng Wen, Yun Zheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ning Yang *Department of Gastroenterology, Xuzhou No.1 People's Hospital, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, 221200, People's Republic of China.ORCID 0000-0001-6666-1440
Lei Zhang *Network and Information Management Department, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230000, People's Republic of China.
Shiyu LiuDepartment of Gastroenterology, Xuzhou No.1 People's Hospital, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, 221200, People's Republic of China.
Zhentao LiDepartment of Gastroenterology, Xuzhou No.1 People's Hospital, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, 221200, People's Republic of China.
Xin YangDepartment of Gastroenterology, Xuzhou No.1 People's Hospital, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, 221200, People's Republic of China.
Chuannan WuDepartment of Gastroenterology, Xuzhou No.1 People's Hospital, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, 221200, People's Republic of China.
Tao LiDepartment of Gastroenterology, Xuzhou No.1 People's Hospital, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, 221200, People's Republic of China.
Hu ChenDepartment of Gastroenterology, Xuzhou No.1 People's Hospital, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, 221200, People's Republic of China.
Yongheng WenDepartment of Gastroenterology, Xuzhou No.1 People's Hospital, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, 221200, People's Republic of China.
Yun ZhengDepartment of Emergency, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People's Republic of China.
Guangxia ChenDepartment of Gastroenterology, Xuzhou No.1 People's Hospital, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, 221200, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Inflammation-based indices derived from complete blood counts (CBC) have emerged as potential prognostic markers in hepatocellular carcinoma (HCC), yet their comparative value in compensated patients remains unclear. This study aimed to evaluate the prognostic significance of seven CBC-derived inflammatory markers in patients with compensated HCC. Methods: This retrospective cohort study included 2802 patients with compensated HCC diagnosed between 2012 and 2025 at the First Affiliated Hospital of Anhui Medical University. Seven inflammatory indices (NLR, dNLR, MLR, NMLR, SIRI, SII, and AISI) were calculated from baseline blood tests. LASSO Cox regression with 10-fold cross-validation was used to select prognostically relevant indices. Restricted cubic spline (RCS) models were used to determine optimal cutoff values. Overall survival (OS) was analyzed using Kaplan-Meier curves and multivariable Cox regression models. Results: MLR, NMLR, and SIRI were identified as significant prognostic markers. RCS-derived cutoffs were 0.27 for MLR, 2.62 for NMLR, and 0.84 for SIRI. Kaplan-Meier analysis showed that high levels of all three indices were significantly associated with worse OS (log-rank Conclusion: These readily available and cost-effective markers (MLR, NMLR, and SIRI) may serve as useful prognostic indicators in patients with compensated HCC.

Indexed as

hepatocellular carcinomamonocyte-to-lymphocyte rationeutrophil plus monocyte-to-lymphocyte ratioprognosissystemic inflammation response index

Identifiers

PMID42582884
PMCPMC13459613

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.