ArticleRSC advances2026
Biocompatible chitosan-coated polydatin@ZIF-8 MOF nanostructures: synthesis, drug delivery and enhanced antibacterial properties.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Zeolitic imidazolate framework-8 (ZIF-8) is a promising nanocarrier for drug delivery due to its tunable porosity, biocompatibility, and pH sensitivity. In this study, a one-pot room-temperature synthesis strategy was developed to encapsulate polydatin (PD) within ZIF-8 (PD@ZIF-8), followed by chitosan (CS) coating (PD@ZIF-8/CS) for improved stability and sustained release of this drug delivery system. FTIR, UV-vis, XRD, DLS and TGA characterization confirmed the successful synthesis of PD@ZIF-8/CS. SEM micrographs revealed the rhombic dodecahedral particles (85.2 nm) of ZIF-8, slightly roughened polyhedral particles (115.4 nm) of PD@ZIF-8 and aggregated particles (294.8 nm) of PD@ZIF-8/CS, confirming CS shell formation. DLS analysis showed hydrodynamic diameters of 99.3 ± 2.1 nm, 112.8 ± 3.4 nm, and 251.7 ± 4.6 nm for ZIF-8, PD@ZIF-8 and PD@ZIF-8/CS, respectively, with the zeta potential shifting from +12.6 to -3.9 mV after CS coating. The PD@ZIF-8 system achieved an outstanding drug-loading efficiency (91.34%) and exhibited pH-dependent release, reaching 92.5% release at pH 5.0 and 37 °C within 72 h, while the CS coating reduced the burst release by ∼35% and prolonged
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