The double-edged sword of daptomycin: a case of daptomycin-induced eosinophilic pneumonia.

Mohammed Najdat Seijari, Fayaz Khan, Taraneh Zamani, Shahla Mallick, Mohammad Nasser Affas, Stephen Beerman

Abstract readCase Reports

In one paragraph

Article in Oxford medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammed Najdat SeijariDepartment of Internal Medicine, Good Samaritan Hospital, TriHealth, 375 Dixmyth Ave, Mount Auburn neighborhood, Cincinnati, OH 45220, United States.

Fayaz KhanDepartment of Internal Medicine, Good Samaritan Hospital, TriHealth, 375 Dixmyth Ave, Mount Auburn neighborhood, Cincinnati, OH 45220, United States.

Taraneh ZamaniDepartment of Internal Medicine, Good Samaritan Hospital, TriHealth, 375 Dixmyth Ave, Mount Auburn neighborhood, Cincinnati, OH 45220, United States.

Shahla MallickDepartment of Pulmonary and Critical Care Medicine, Good Samaritan Hospital, TriHealth, 375 Dixmyth Ave, Mount Auburn, Cincinnati, OH 45220, United States.

Mohammad Nasser AffasDepartment of Internal Medicine, Hamad Medical Corporation, Al Rayyan Road, Hamad Medical City, Doha, Qatar.ORCID https://orcid.org/0000-0001-6189-2784

Stephen BeermanDepartment of Internal Medicine, Good Samaritan Hospital, TriHealth, 375 Dixmyth Ave, Mount Auburn neighborhood, Cincinnati, OH 45220, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Daptomycin is an effective antibiotic for resistant gram-positive infections, including MRSA and VRE, but can rarely cause daptomycin-induced eosinophilic pneumonia (DIEP). We present a 73-year-old woman treated for prosthetic joint infection who developed acute hypoxemic respiratory failure and peripheral eosinophilia after 21 days of daptomycin therapy. Chest imaging showed bilateral upper lobe consolidations. Symptoms resolved rapidly after stopping daptomycin, without corticosteroid use. This case highlights the need for early recognition of DIEP in patients presenting with new respiratory symptoms and eosinophilia during daptomycin therapy, enabling timely discontinuation and reducing potential morbidity.

Indexed as

Antibiotic toxicityDaptomycinDrug-induced lung diseaseEosinophilic pneumonia

Identifiers

PMID42583159

DOI10.1093/omcr/omag146

PMCPMC13459500

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