Evidence map›Paper›PMID 42583287›Full record

ArticleJournal of thoracic disease2026

Immunocyte phenotypes underlying the causal autoimmune features in narcolepsy type 1.

Tianlong Li, Yabang Chen, Pingan Zhang, Qingqian Zhu, Zhuoshen Lin, Baoxin Peng, Rundong Qin, Nicolas Steenbergen, Rulong Hu, Hua Qin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tianlong Li *State Key Laboratory of Respiratory Disease, Department of Otolaryngology, Head & Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yabang Chen *State Key Laboratory of Respiratory Disease, Department of Otolaryngology, Head & Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Pingan Zhang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health.
Qingqian ZhuState Key Laboratory of Respiratory Disease, Department of Otolaryngology, Head & Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhuoshen LinState Key Laboratory of Respiratory Disease, Department of Otolaryngology, Head & Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Baoxin PengState Key Laboratory of Respiratory Disease, Department of Otolaryngology, Head & Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Rundong QinState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health.
Nicolas SteenbergenDepartment of Bioengineering, Imperial College London, London, UK.
Rulong HuState Key Laboratory of Respiratory Disease, Department of Otolaryngology, Head & Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Hua QinState Key Laboratory of Respiratory Disease, Department of Otolaryngology, Head & Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaowen ZhangState Key Laboratory of Respiratory Disease, Department of Otolaryngology, Head & Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Narcolepsy is a neurological sleep disorder associated with immune response. However, the autoimmune basis for narcolepsy remains unclear. This study aimed to evaluate the causal relationship between immune cells and narcolepsy type 1 (NT1). Methods: We used a two-sample Mendelian randomization (MR) method to investigate the associations between 731 immune cell traits and NT1 based on a genome-wide association study (GWAS) database from the FinnGen consortium. The inverse-variance weighted (IVW) method was used as the primary method, followed by sensitivity analyses, including the MR-Egger intercept test, Cochran's Q test, and MR pleiotropy residual sum and outlier (MR-PRESSO). Additional mediation analysis was conducted to investigate the mediating effect of 91 cytokines on immune cells to facilitate the immune processes in NT1. Results: Immune cell traits showed significant causal associations with NT1. Risk-associated traits mainly involved human leukocyte antigen-DR (HLA-DR)-related monocyte phenotypes, T-cell-related traits, natural killer (NK) cell-related traits, and natural killer T (NKT) cell-related traits, whereas protective traits mainly involved CD4+ T-cell-related, plasmacytoid dendritic cell-related, monocyte-related, and B-cell-related phenotypes. Overall, ten immune cell traits were associated with an increased risk of narcolepsy, whereas five were associated with a reduced risk. Mediation analysis further indicated that interleukin-6 (IL-6) mediates the immune-inflammatory pathway linking monocyte-related traits to NT1. These findings remained consistent in all sensitivity analyses. Conclusions: Our study identified immunophenotypes that are related to the development of NT1, providing insight into the autoimmune pathogenesis of NT1 and subsequent immunotherapy.

Indexed as

cytokinesimmune cell traitsimmunocyte phenotypesMendelian randomization (MR)Narcolepsy

Identifiers

PMID42583287
PMCPMC13460202

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.