ArticleJournal of thoracic disease2026
Prognostic impact of preoperative immunenutritional indices in patients undergoing curative resection for non-small cell lung cancer: a retrospective analysis.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in non-small cell lung cancer (NSCLC) has been widely reported; however, its utility in predicting recurrence after complete resection, particularly in early-stage disease, remains unclear. This study aimed to evaluate the prognostic value of preoperative NLR and compare it with other immunonutritional indices. Methods: We retrospectively analyzed 789 patients who underwent complete resection for NSCLC between 2012 and 2022. Patients with infection, inflammatory disease, neoadjuvant therapy, or incomplete data were excluded. Recurrence-free survival (RFS) was assessed in the overall cohort (Cohort 1) and in patients with pathological stage I disease (Cohort 2). Optimal cutoff values for NLR, prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI), and controlling nutritional status (CONUT) score were determined using receiver operating characteristic analysis. Cox proportional hazards models were used to identify predictors of recurrence. Results: Recurrence occurred in 22.6% of patients. High preoperative NLR was significantly associated with poorer RFS in both Cohort 1 (5-year RFS: 67.8% Conclusions: Preoperative NLR is a simple and clinically useful biomarker for predicting postoperative recurrence in patients with completely resected stage I NSCLC. Its prognostic value appears limited in the overall population but remains significant in early-stage disease. Incorporating NLR into perioperative risk stratification may improve identification of high-risk patients and guide postoperative surveillance strategies. Further prospective validation is warranted.
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