Evidence map›Paper›PMID 42583543›Full record

ArticleJournal of thoracic disease2026

LTB4R inhibits apoptosis and induces radiosensitivity by promoting the PI3K/AKT pathway in esophageal squamous cell carcinoma.

Yanhui Li, Dehua Ma, Jiawei Liang, Jianlei Yu, Hanxi Zhou, Hao Liu, Ying Zhang, Pengfei Sheng, Minhua Ye, Chunguo Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yanhui Li *School of Pharmacy, Hangzhou Medical College, Hangzhou, China.
Dehua Ma *Department of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Jiawei Liang *Department of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Jianlei YuDepartment of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Hanxi ZhouDepartment of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Hao LiuDepartment of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Ying ZhangDepartment of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Pengfei ShengDepartment of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Minhua YeDepartment of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Chunguo WangDepartment of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Min KongDepartment of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Xuelian ChenDepartment of Radiology, Kunshan First People's Hospital, Kunshan, China.
Jianfei ShenSchool of Pharmacy, Hangzhou Medical College, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Radiotherapy (RT) is a critical treatment modality for esophageal squamous cell carcinoma (ESCC), yet radioresistance poses a major clinical challenge. Prior studies have reported elevated leukotriene B4 receptor (LTB4R) expression in ESCC tissues versus adjacent normal tissues, where it promotes cell proliferation, invasion, and metastasis. However, the correlation between LTB4R expression and ESCC radioresponsiveness remains uninvestigated. This study aimed to clarify LTB4R's role in regulating ESCC cell sensitivity to RT and its underlying molecular mechanisms. Methods: Results: LTB4R knockdown suppressed malignant phenotypes of ESCC cells after RT Conclusions: LTB4R regulates ESCC radioresponse via the PI3K/AKT-apoptosis axis, and holds potential as a predictive biomarker for RT efficacy in ESCC.

Indexed as

esophageal cancer (EC)esophageal squamous cell carcinoma (ESCC)Leukotriene B4 receptor (LTB4R)radiosensitivityradiotherapy resistance (RT resistance)

Identifiers

PMID42583543
PMCPMC13460194

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.