ArticlePhysiological reports2026
Ventricular-vascular coupling at rest and immediately following maximal exercise in adults with and without multiple sclerosis.
Brooks A Hibner, Natalia S Lima, Sara R Sherman, Robert W Motl, Julio A Chirinos, Shane Phillips, Philip S Clifford, Anthony T Reder, Tracy Baynard, Bo Fernhall
Abstract read
In one paragraphArticle in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Natalia S LimaIntegrative Physiology Laboratory, University of Illinois at Chicago, Chicago, Illinois, USA.
Robert W MotlIntegrative Physiology Laboratory, University of Illinois at Chicago, Chicago, Illinois, USA.
Julio A ChirinosHospital of the University of Pennsylvania, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Shane PhillipsDepartment of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois, USA.
Anthony T RederDepartment of Neurology, University of Chicago Medicine, Chicago, Illinois, USA.
Tracy BaynardDepartment of Exercise and Health Sciences, University of Massachusetts Boston, Boston, Massachusetts, USA.
Funding
Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4MVASCULAR EFFECTS OF DIETARY SALT IN HUMANS WITH SALT-RESISTANT BPR01HL104106 · NHLBI · UNIVERSITY OF DELAWARE · PI EDWARDS, DAVID G, FARQUHAR, WILLIAM B · 2011 to 2021
$4.5MTargeting Skeletal Muscle Perfusion and Oxidative Capacity in HFpEFR01HL155599 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ZAMANI, PAYMAN · 2021 to 2025
$3.9MCardiovascular Risk, Vascular and Kidney Damage in COVID-19 SurvivorsR01HL157108 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JULIO ALONSO CHIRINOS MEDINA, Jordana B. Cohen · 2022 to 2026
$3.9MBlockade of calcium channels and beta adrenergic receptors for physiologic abnormalities in heart failure with preserved ejection fraction (BLOCK HFpEF)R01HL153646 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI COHEN, JORDANA B. · 2020 to 2024
$3.2MCardiovascular Consequences of Duchenne and Becker Muscular DystrophinopathiesR01HL155764 · NHLBI · UNIVERSITY OF DELAWARE · PI WITMAN, MELISSA A.H. · 2021 to 2025
$3.1MEfficacy of Fenofibrate for COVID-19: A phase II randomized controlled trialU01TR003734 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2021 to 2021
$1.8MHeartShare: Next-Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets - Clinical CentersU01HL160277 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JULIO ALONSO CHIRINOS MEDINA · 2021 to 2026
$1.7MGenetic determinants of thoracic aortic stiffness and remodelingK24AG070459 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2021 to 2025
$975kAmerican College of Sports Medicine (ACSM) 21-01556DOD | US Army | MEDCOM | Armed Forces Institute of Regenerative Medicine (AFIRM) W81XWH1810466NCATS NIH HHS U01 TR003734NHLBI NIH HHS R01 HL104106NHLBI NIH HHS R01 HL153646NHLBI NIH HHS R01 HL155599NHLBI NIH HHS R01 HL155764NHLBI NIH HHS R01 HL157108NHLBI NIH HHS U01 HL160277NIA NIH HHS K24 AG070459NIA NIH HHS R01 AG058969NIH HHS K24-AG070459NIH HHS R01-AG058969NIH HHS R01-HL104106NIH HHS R01-HL153646NIH HHS R01-HL155599NIH HHS R01HL155764NIH HHS R01-HL157108NIH HHS R33-HL-146390NIH HHS U01-TR003734NIH HHS U01-TR003734-01S1NIH HHS UO1-HL160277
6 · The paper itselfAbstract
Multiple sclerosis (MS) may impair ventricular-vascular coupling (VVC), a measure of the interaction between the cardiac and vascular systems. We evaluated if VVC differed between individuals with and without MS with similar age-predicted fitness. Individuals with MS (n = 20) and without (CON, n = 18) underwent VVC measurement before and immediately after a maximal incremental cycle test with peak oxygen consumption (VO
Indexed as
ExerciseMultiple SclerosisAdultFemaleHumansMaleMiddle AgedOxygen ConsumptionRestStroke Volumecardiovascular functionexercise recoverymultiple sclerosisventricular‐vascular coupling
Identifiers
PMID42583774
PMCPMC13463308
What Socratic holds
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