Evidence mapPaperPMID 42583814Full record

ArticleEndocrinology, diabetes & metabolism2026

The Association Between Atherogenic Index of Plasma and Type 2 Diabetes Mellitus in a Multi-Ethnic Population of Premature Coronary Artery Disease Patients: Insights From IPAD Study.

Reza Amani-Beni, Ghazal Ghasempour Dabaghi, Noushin Mohammadifard, Ehsan Zarepur, Bahar Darouei, Mehrdad Rabiee Rad, Fahimeh Haghighatdoost, Fatemeh Nouri, Nizal Sarrafzadegan

Abstract read
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Article in Endocrinology, diabetes & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Reza Amani-BeniIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID https://orcid.org/0000-0002-8383-6676
Ghazal Ghasempour DabaghiIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Noushin MohammadifardIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID https://orcid.org/0000-0003-1776-1060
Ehsan ZarepurIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID https://orcid.org/0000-0002-1803-5119
Bahar DaroueiIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID https://orcid.org/0000-0002-5269-0061
Mehrdad Rabiee RadIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID https://orcid.org/0000-0001-6800-6925
Fahimeh HaghighatdoostHeart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID https://orcid.org/0000-0003-4766-6267
Fatemeh NouriIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID https://orcid.org/0000-0002-0191-7668
Nizal SarrafzadeganIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID https://orcid.org/0000-0002-6828-2169

Funding

Iran Ministry of Health and Medical Education #96110
6 · The paper itself

Abstract

backgroundThe atherogenic index of plasma (AIP) is a lipid-based indicator of cardiometabolic risk. We examined whether AIP is associated with prevalent type 2 diabetes mellitus (T2DM) and fasting blood sugar (FBS) in patients with premature coronary artery disease (PCAD) and explored whether this association differed across Iranian ethnic groups.

methodsWe analysed 2143 patients with angiographically confirmed PCAD from the Iran Premature Coronary Artery Disease (IPAD) study, of whom 1945 had valid AIP data. CAD was defined as ≥ 50% stenosis in the left main artery or ≥ 75% stenosis in another major coronary vessel. AIP was calculated as log

resultsIn the fully adjusted model, including lipid-lowering medication use, participants in the highest AIP quartile had higher odds of prevalent T2DM than those in the lowest quartile (OR: 1.57; 95% CI: 1.14, 2.16; p = 0.005; P for trend = 0.002). Each 1-unit increase in AIP was associated with higher odds of prevalent T2DM (OR: 1.99; 95% CI: 1.26, 3.14; p = 0.003). Higher AIP was also associated with higher FBS; compared with the lowest quartile, the highest quartile had a 15.23 mg/dL higher FBS level in the fully adjusted model (95% CI: 7.61, 22.84; p < 0.001). In exploratory ethnicity-stratified analyses, the association was most evident in the Fars subgroup, while estimates in several smaller ethnic groups were imprecise.

conclusionsHigher AIP was associated with prevalent T2DM and higher FBS in patients with PCAD. Exploratory analyses suggested possible ethnicity-related heterogeneity, but these subgroup findings should be interpreted cautiously. Prospective studies are needed to determine whether AIP has predictive or clinical risk-stratification value in this population.

Indexed as

AtherosclerosisCoronary Artery DiseaseDiabetes Mellitus, Type 2AdultBlood GlucoseEthnicityFemaleHumansIranMaleMiddle AgedPrevalenceRisk FactorsBlood Glucoseatherogenic index of plasmacoronary artery diseaseethnicityinsulin resistancetype 2 diabetes mellitus

Identifiers

PMID42583814
PMCPMC13463314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.