Virus-like Particles Derived from Bacteriophage Beihai32 as a Versatile Carrier for Displaying Large Peptide Antigens.

Anna A Zykova, Elena A Blokhina, Marina A Shuklina, Olga O Ozhereleva, Sergey A Klotchenko, Eugenia S Mardanova, Nikolai V Ravin

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Article in Nanomaterials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

7 authors.

Anna A ZykovaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0001-9577-4815

Elena A BlokhinaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0002-6038-3715

Marina A ShuklinaSmorodintsev Research Institute of Influenza, Russian Ministry of Health, 197376 St. Petersburg, Russia.ORCID 0000-0002-7550-5519

Olga O OzherelevaSmorodintsev Research Institute of Influenza, Russian Ministry of Health, 197376 St. Petersburg, Russia.ORCID 0000-0001-9489-6095

Sergey A KlotchenkoSmorodintsev Research Institute of Influenza, Russian Ministry of Health, 197376 St. Petersburg, Russia.ORCID 0000-0003-0289-6560

Eugenia S MardanovaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0003-2148-7658

Nikolai V RavinInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0002-1456-1832

Funding

Russian Science Foundation 25-14-00226

6 · The paper itself

Abstract

Virus-like particles (VLPs) based on the capsid protein (CP) of the ssRNA bacteriophage Beihai32 represent a promising nanoscale platform for the presentation of heterologous peptides. Previous studies have shown that the C-terminus of the CP tolerates long insertions without compromising VLP assembly. Here, we demonstrate that the N-terminus is similarly permissive to extended insertions. Hybrid CPs with one to four copies of the influenza A virus M2e peptide fused to the N-terminus were expressed in

Indexed as

influenza A virusM2e peptidessRNA bacteriophagevaccine platformvirus-like particleVLP vaccine

Identifiers

PMID42584325

DOI10.3390/nano16150932

PMCPMC13468365

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.