ArticleJACC. Asia2026
Determinants and Prognostic Impact of Left Atrial Reservoir Strain Improvement Following Mitral Transcatheter Edge-to-Edge Repair.
Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart failure with functional mitral regurgitation (FMR) has poor prognosis, and mitral transcatheter edge-to-edge repair (M-TEER) is an effective treatment. However, patient responses are variable, highlighting the need for early markers of treatment success. Left atrial reservoir strain (LARS) reflects atrial compliance and chronic hemodynamic burden and may identify patients with reversible atrial dysfunction. We retrospectively analyzed 128 patients with FMR (median age 80 years, 37% female; 31% atrial subtype) undergoing M-TEER at Hiroshima University Hospital. LARS was measured at baseline and 1 month postprocedure, with improvement defined as ≥15% relative increase. Procedural success was high (98%), and LARS assessment showed excellent reproducibility. LARS improved in 33% of patients. Key predictors of early improvement were absence of persistent atrial fibrillation, lower baseline LARS, and better renal function. Procedural factors such as residual mitral regurgitation or transmitral gradient were not associated. Patients with LARS improvement showed greater reductions in pulmonary arterial wedge pressure, improved biventricular function, lower residual tricuspid regurgitation, and enhanced exercise capacity. During a median follow-up of 14 months, early LARS improvement was associated with significantly higher event-free survival. Multivariable analysis confirmed that LARS improvement independently predicted lower risk of all-cause death and heart failure hospitalization, beyond baseline LARS and conventional post-M-TEER risk factors. Continuous analysis of %ΔLARS further supported a dose-response relationship with outcomes. In summary, early LARS improvement reflects integrated atrial and cardiopulmonary reverse remodeling and is a strong independent predictor of short-term prognosis after M-TEER. Serial assessment of LARS shortly after M-TEER may serve as a practical tool for early risk stratification and therapeutic optimization across all FMR subtypes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.