Evidence map›Paper›PMID 42584508›Full record

ArticleMikrochimica acta2026

A cascade-amplified Fe

Zhiqiang Guo, Haiping Zhang, Xianrong Xing, Xinru Ren, Yu Wang, Su Liu, Jiadong Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhiqiang GuoKey Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, P.R. China.
Haiping ZhangKey Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, P.R. China.
Xianrong XingDepartment of Pharmacy, Shandong Medical College, Jinan, 250022, P.R. China.
Xinru RenKey Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, P.R. China.
Yu WangSchool of Biological Sciences and Technology, University of Jinan, Jinan, 250022, P.R. China.
Su LiuSchool of Water Conservancy and Environment, University of Jinan, Jinan, 250022, P.R. China.
Jiadong HuangKey Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, P.R. China. chm_huangjd@ujn.edu.cn.

Funding

Jinan City-College Collaborative Development Strategic Project JNSX2024027National Natural Science Foundation of China 32072330Natural Science Foundation of Shandong Province ZR2022MB066Natural Science Foundation of Shandong Province ZR2024MC007
6 · The paper itself

Abstract

A miRNA-21-responsive analytical nanoplatform based on Fe₃O₄@polydopamine (PDA) was constructed for co-delivery of doxorubicin (DOX) and functional nucleic acids, with glucose oxidase (GOx) immobilized to achieve cascade-amplified combined therapeutic effects; notably, the proposed self-supplying oxidative cascade is a proof-of-concept deduction based on indirect evidence. The platform enables targeted recognition and specific binding to tumor cells via the sgc8 aptamer. Following cellular internalization, endogenous miRNA-21 triggers the catalytic hairpin assembly (CHA) reaction, enabling DOX release and DNAzyme generation with high specificity for miRNA-21 detection. The DNAzyme downregulates the expression of proliferation-promoting and ferroptosis-suppressing proteins, working in conjunction with DOX to promote tumor cell apoptosis. Concurrently, ferrous ions (Fe

Indexed as

ApoptosisFerroptosisMicroRNAsAptamers, NucleotideBiosensing TechniquesDNA, CatalyticDoxorubicinFerrosoferric OxideGlucose OxidaseHumansIndolesMCF-7 CellsPolymersAptamers, NucleotideDNA, CatalyticDoxorubicinFerrosoferric OxideGlucose OxidaseIndolesMicroRNAsMIRN21 microRNA, humanpolydopaminePolymersApoptosisCatalytic hairpin assemblyFe₃O₄ nanoplatformFerroptosisMiRNA‑21 sensingTumor therapy

Identifiers

PMID42584508

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.