Evidence map›Paper›PMID 42584755›Full record

ArticleCell biochemistry and biophysics2026

Phytochemical Profiling and Multifunctional Bioactivities of Pergularia tomentosa L. Latex: Angiogenic Potential via the CAM Model, Accelerated Burn Wound Healing in Rats, and In Vitro Antioxidant and Antibacterial Evaluation.

Khaoula Segueni, Atef Chouikh, Yahia Khelef, Mohammed Laid Tlili, Abderrhmane Bouafia, Abir Benaissa, Hatem M M Mazroaa, Khuzama M S Al-Essa, Salah Eddine Laouini, Farid Menaa

Abstract read
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Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Khaoula SegueniLaboratory of Biology, Environment and Health (LBEH), University of El Oued, El Oued, 39000, Algeria.ORCID http://orcid.org/0000-0001-5336-0622
Atef ChouikhLaboratory of Biology, Environment and Health (LBEH), University of El Oued, El Oued, 39000, Algeria.ORCID http://orcid.org/0000-0002-6356-4271
Yahia KhelefLaboratory of Biology, Environment and Health (LBEH), University of El Oued, El Oued, 39000, Algeria.
Mohammed Laid TliliLaboratory of Biology, Environment and Health (LBEH), University of El Oued, El Oued, 39000, Algeria.
Abderrhmane BouafiaDepartment of Process Engineering and Petrochemical, Faculty of Technology, University of El Oued, P.O. Box 789, El Oued, 39000, Algeria. bouafia-abderrhmane@univ-eloued.dz.ORCID http://orcid.org/0000-0001-5266-7796
Abir BenaissaDepartment of Process Engineering and Petrochemical, Faculty of Technology, University of El Oued, P.O. Box 789, El Oued, 39000, Algeria.
Hatem M M MazroaaKing Faisal University, Al-Ahsa, 31982, Saudi Arabia.
Khuzama M S Al-EssaKing Faisal University, Al-Ahsa, 31982, Saudi Arabia.
Salah Eddine LaouiniDepartment of Process Engineering and Petrochemical, Faculty of Technology, University of El Oued, P.O. Box 789, El Oued, 39000, Algeria.ORCID http://orcid.org/0000-0002-6609-4623
Farid MenaaDepartment of Biomedical and Environmental Engineering (BEE), Fluorotronics, Inc.-California Innovations Corporation, San Diego, CA, 92037, USA. menaateam@gmail.com.ORCID http://orcid.org/0000-0002-0258-7322

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Burn wounds represent a major clinical challenge due to delayed healing, high infection risk, and the limitations of current therapeutic agents. This study investigated the phytochemical composition and multifunctional bioactivities of Pergularia tomentosa L. latex as a potential natural therapeutic for burn wound management. Phytochemical screening identified phenolic compounds, flavonoids, tannins, alkaloids, terpenoids, and saponins, with substantial quantities of lipids (105.95 ± 0.01 mg ESO/g), proteins (97.91 ± 0.02 mg EBSA/g), and carbohydrates (229.92 ± 0.03 mg EG/g), supported by FTIR spectral analysis. The latex demonstrated a sun protection factor of 12.78, moderate hydroxyl radical scavenging activity (IC₅₀: 102.16 ± 7.00 mg/mL), antioxidant capacity (46.64 ± 0.003 EAA/g), and erythrocyte membrane protection against oxidative hemolysis. Antibacterial assays revealed broad-spectrum activity with a minimum inhibitory concentration of 0.9375 mg/mL against all tested strains. The chorioallantoic membrane assay confirmed marked pro-angiogenic activity with enhanced neovascularization and vascular branching at lower concentrations. In vivo evaluation in a rat burn model showed that topical formulations containing 2% and 7% latex significantly accelerated wound closure and tissue repair over 22 days compared with controls (p < 0.001), with near-complete re-epithelialization observed in the 7% formulation group. These findings support the therapeutic potential of P. tomentosa latex as a multifunctional natural candidate for burn wound management and tissue regeneration.

Indexed as

Anti-Bacterial AgentsAntioxidantsApocynaceaeBurnsLatexNeovascularization, PhysiologicPhytochemicalsWound HealingAnimalsChorioallantoic MembraneHemolysisMaleMicrobial Sensitivity TestsPlant ExtractsRatsAnti-Bacterial AgentsAntioxidantsLatexPhytochemicalsPlant Extractsangiogenesisantibacterial activityantioxidant activityburn wound healinglatexPergularia tomentosa L

Identifiers

PMID42584755

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.