Evidence map›Paper›PMID 42584792›Full record

ArticleEuropean geriatric medicine2026

Fall-Risk-Increasing drugs and falls in community-dwelling older adults: a prospective cohort study in a single Danish municipality.

Thorbjørn Irskov Mortensen, Gustav Valentin Gade, Martin Grønbech Jørgensen, Lotta Seppala, Nathalie van der Velde, Tahir Masud, Jesper Ryg

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Article in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thorbjørn Irskov MortensenDepartment of Clinical Research, Geriatric Research Unit, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0009-0002-2074-662X
Gustav Valentin GadeDepartment of Geriatric Medicine, Aalborg University Hospital, Aalborg, Denmark.ORCID http://orcid.org/0000-0002-7944-9913
Martin Grønbech JørgensenDepartment of Geriatric Medicine, Aalborg University Hospital, Aalborg, Denmark.ORCID http://orcid.org/0000-0002-3189-644X
Lotta SeppalaDepartment of Internal Medicine, Section of Geriatric Medicine, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9197-1424
Nathalie van der VeldeDepartment of Internal Medicine, Section of Geriatric Medicine, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6477-6209
Tahir MasudDepartment of Clinical Research, Geriatric Research Unit, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0003-1061-2898
Jesper RygDepartment of Clinical Research, Geriatric Research Unit, University of Southern Denmark, Odense, Denmark. jesper.ryg@regionh.dk.ORCID http://orcid.org/0000-0002-8641-3062

Funding

A.P. Møller Lægefonden 18-L-0377
6 · The paper itself

Abstract

purposeFall-risk-increasing drugs (FRIDs) are a significant and modifiable risk factor for falls in older adults. However, prospective data using robust fall ascertainment on specific FRID classes are scarce in community-dwelling populations. We aimed to investigate the association between individual FRID classes and both single and recurrent falls in older community-dwelling adults.

methodsWe analysed data from a Danish prospective cohort of 241 community-dwelling adults aged ≥ 75 years. Medication records were collected at baseline, and drugs were classified using the STOPPFall consensus FRIDs list. Falls were recorded prospectively for 1 year using monthly fall-calendars, verified using telephone follow-ups. Associations between FRIDs and one-time (1 fall) and recurrent falls (≥ 2 falls) were explored using Cox proportional hazards model, adjusting for clinical and sociodemographic factors.

resultsThe median (IQR) age was 82 (80, 86) years, 66.4% were women, and 43.6% had a positive fall history. Prevalences of polypharmacy and use of any FRID were 70.5% and 73.9%, respectively. During follow-up, 88 participants (36.5%) fell at least once while 41 participants (17.0%) fell twice or more. The total number of FRIDs was not associated with falls. Baseline use of benzodiazepine-related drugs, strong anticholinergics, and antiepileptics were significantly associated with recurrent falls in the fully adjusted analyses with hazard ratios (95% confidence intervals) of 3.34 (1.28-8.75), 2.48 (1.04-5.89), and 4.78 (1.24-18.35), respectively.

conclusionSeveral specific FRID classes were significantly associated with recurrent falls in this cohort of well-functioning community-dwelling adults, highlighting the importance of targeted medication review and careful prescribing strategies.

Indexed as

Adverse drug eventsFall-risk-increasing drugsFallsOlder adultsProspective studyRecurrent falls

Identifiers

PMID42584792

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.