Evidence map›Paper›PMID 42584938›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Single-Cell Profiling Reveals a Protective WNT5A-ATF3-FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia.

Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang and 1 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ruiyu LuoDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0009-0003-9949-2841
Ke FangSchool of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0009-0004-8155-7325
Changjiang ZhaoDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiachao XiongDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0003-3002-1171
Yuan ZhuDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Mingyang LuDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
He YanDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Zihan LiSt. Hugh's College, University of Oxford, Oxford, UK.
Baojin WuDepartment of Plastic Surgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-9832-9933
Hua JiangDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yufei LiDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0009-0004-5869-9309

Funding

Featured Clinical Discipline Project of Shanghai Pudong PWYts2021-07National Fund of the Education Ministry 231103242232720National Natural Science Foundation of China 82503037Shanghai East Hospital Clinical Research Plan SEHHH-2021(KJ)-0669-KJB-485Shanghai East Hospital Clinical Research Plan SEHHH-2023(K)-0143-KYB-111
6 · The paper itself

Abstract

Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options, driven by poorly understood molecular mechanisms. Using single-cell RNA sequencing of human scalp follicles from balding and non-balding regions, we constructed a high-resolution molecular anatomy atlas of the hair follicle and its microenvironment. We identified significant silencing of Wingless-related integration site 5A (WNT5A) signaling, which was widely known as the trigger of non-canonical WNT signaling pathway, in hair follicle stem cells (HFSCs) from balding areas, leading to downregulation of the transcription factor ATF3 and its target FOSB. Therapeutically, functional validation showed that activating the WNT5A-ATF3-FOSB axis maintained HFSC competence in AGA murine models and significantly inhibited the progression of AGA. Our findings reveal a critical molecular axis in AGA pathogenesis, highlighting its potential as a therapeutic target for hair loss disorders.

Indexed as

androgenetic alopeciaATF3hair follicle stem cellsingle‐cell analysisWNT5A

Identifiers

PMID42584938
PMCPMC13464553

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.