ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
m6A-Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood. Our population-based study showed elevated ferroptosis levels in all-cause FGR placentae. Environmental stressor cadmium (Cd) was used to generate an FGR mouse model, which exhibited elevated placental ferroptosis. Ferroptosis inhibitor ferrostatin-1 reversed environmental Cd-induced FGR. Targeted oxidized lipidomics identified the peroxisome as a target organelle for prenatal Cd-induced placental ferroptosis. Furthermore, Cd induced excessive activation of PEX5-dependent pexophagy in placentae. By establishing a placental Pex5-knockdown mouse, pexophagy was confirmed to drive environmental Cd-induced placental ferroptosis. Mechanistically, pexophagy drives the degradation of the H
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