Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Einstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VIJG, JAN · 2010 to 2024
$10.8M
Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0M
Cellular Approaches to Tissue Engineering/RegenerationT32EB001026 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN, ANDREW W, MONGA, SATDARSHAN SINGH · 2003 to 2024
$5.5M
Neurobiology Core CP30AR079206 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI Anne-Marie Malfait · 2021 to 2026
$4.7M
Testing Miniature Knee Joint System as a New Tool to Study Neuroimmune Interactions in Osteoarthritis PainF31AR083814 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKARCZYK, MEAGAN JOANNE · 2024 to 2025
$99k
Cellular Approaches to Tissue Engineering and Regeneration, Cardiovascular Bioengineering Training Program T32- HL076124NHLBI NIH HHS T32 HL076124NIAMS NIH HHS F31 AR083814NIAMS NIH HHS P30 AR079206NIA NIH HHS P30 AG038072NIBIB NIH HHS T32 EB001026Ruth L Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) 1F31AR083814 - 01A1University of Pittsburgh School of Medicine Department of Orthopaedic Surgery Startup FundUniversity of Pittsburgh School of Medicine Orland Bethel Family Musculoskeletal Research Center (BMRC)
6 · The paper itself
Abstract
Although the causal association between aging and osteoarthritis (OA) has been documented, our understanding of the underlying mechanism remains incomplete. To define the regulatory molecules governing chondrocyte aging, we performed transcriptomic analysis of young and old human chondrocytes from healthy donors. The data predicted that GATA-binding protein 4 (GATA4) may play a key role in mediating the difference between young and old chondrocytes. Results from immunostaining and western blot showed significantly higher GATA4 levels in old human or mouse chondrocytes when compared to young cells. Moreover, overexpressing
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Aging-associated increase of GATA4 levels in articular cartilage is linked to impaired regenerative capacity of chondrocytes and osteoarthritis. · full record | Socratic