ArticlePloS one2026
Apoptosis-related genes bridge inflammatory bowel disease and osteoporosis: A bioinformatic analysis.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory bowel disease (IBD) and osteoporosis (OP) often co-occur, with IBD accelerating OP onset, though the underlying mechanisms remain unclear.
methodsBased on gene expression data from the GEO database, differential expression analysis was performed using the limma package to identify genes dysregulated in both IBD and OP. Weighted Gene Co-expression Network Analysis (WGCNA) was employed to explore the associations between genes and phenotypes. Candidate genes were obtained by intersecting differentially expressed genes with key WGCNA modules, followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. To further focus on apoptosis-related mechanisms, the candidate genes were intersected with an apoptosis-related gene set and refined using lasso regression. Core genes were identified through differential expression validation and receiver operating characteristic curve analysis. Subsequently, their potential functions and regulatory networks were explored via multidimensional analysis, gene set enrichment analysis, and Pearson correlation analysis.
resultsWNT1 and S100A8 are closely associated with the progression of both inflammatory bowel disease and osteoporosis. Gene Set Enrichment Analysis revealed that WNT1 is primarily enriched in cell cycle checkpoint signaling, chromosome organization, neuroactive ligand signaling, and neuroactive ligand-receptor interaction. In contrast, S100A8 is mainly enriched in adaptive immune response, adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily, inflammatory bowel disease, and leishmaniasis. Pearson correlation analysis showed that WNT1 is correlated with TSPAN32, POU3F3, NXPH3, EGFL7, LHX3, TNNI2, HMX1, FAM3A, IBTK, and ZNF747, while S100A8 is correlated with MMP3, SLC6A14, MMP10, S100A9, AQP9, S100A12, CXCL6, CXCR1, SLC38A4, and NCF2.
conclusionsWNT1 and S100A8, which are associated with apoptosis, play critical roles in both inflammatory bowel disease and osteoporosis, providing new potential therapeutic targets and a theoretical basis for clinical diagnosis and treatment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.