Evidence map›Paper›PMID 42586554›Full record

ArticleClinical and experimental pharmacology & physiology2026

Ca

Tingting Deng, Wen Zhang, Jiahui Meng, Jie Gao, Chang Gao, Shiyu Li, Jiaxing Wang, Zijian Zeng, Yongjing Zhang, Nan Wang

Abstract read
In one paragraph

Article in Clinical and experimental pharmacology & physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tingting DengSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
Wen ZhangNorinco General Hospital, Xi'an, China.
Jiahui MengSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
Jie GaoSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, China.ORCID https://orcid.org/0009-0009-6480-2524
Chang GaoSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
Shiyu LiSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
Jiaxing WangSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
Zijian ZengSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
Yongjing ZhangSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
Nan WangSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, China.ORCID https://orcid.org/0000-0002-4197-4245

Funding

Fundamental Research Funds for the Central Universities xzy012024155National Natural Science Foundation of China 82274063
6 · The paper itself

Abstract

backgroundFood allergy (FA) is a disorder marked by a significant incidence of detrimental immunological responses to certain dietary constituents, while preventive measures and regulatory treatments are scarce. Mast cells (MCs) are integral to the pathogenesis of FA mediated by Immunoglobulin E (IgE). The activation of MCs is modulated by their intracellular Ca

objectiveThe aim of this study was to examine the influence of Ca

methodsThe inhibitory effect of nimodipine (Nim) on MCs activation in vitro was evaluated by detecting LAD2 degranulation and cytokine release; the anti-food allergy effect of Nim was examined by the establishment of an IgE-mediated FA model; the effect of Ca

resultsNim inhibited MCs activation in vitro and alleviated ovalbumin (OVA)-induced FA in vivo. The expression of Ca

conclusionDepression of Ca

Indexed as

Calcium Channels, L-TypeFood HypersensitivityImmunoglobulin EMast CellsAnimalsCell DegranulationMiceMice, Inbred C57BLMice, KnockoutNimodipineCalcium Channels, L-TypeImmunoglobulin ENimodipineCaV1.2food allergyIgEmast cell

Identifiers

PMID42586554
PMCPMC13467469

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.