Evidence map›Paper›PMID 42587010›Full record

ReviewMolecular psychiatry2026

The NLRP3 inflammasome: pathophysiology and therapeutic implications for schizophrenia and neuropsychiatric disorders.

Jonah Im, Madeline Mai, Kailin Mimaki, Lara Tang, Stephen Marder, Yvonne Yang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonah ImDavid Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA. jonahim@mednet.ucla.edu.ORCID http://orcid.org/0009-0008-3564-7548
Madeline MaiCollege of Letters and Science, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA.
Kailin MimakiCollege of Letters and Science, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA.
Lara TangDavid Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.
Stephen MarderDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90095, USA.
Yvonne YangDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90095, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia is a complex psychiatric disorder with an incompletely understood etiology, but converging evidence supports a role for chronic neuroinflammation in its pathogenesis. The nucleotide-binding oligomerization domain-, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome is a central regulator of innate immune responses in the central nervous system and has been implicated in several neuropsychiatric disorders. Emerging evidence links dysregulated NLRP3 activity to inflammatory and structural brain changes relevant to schizophrenia, though direct clinical evidence remains limited and causal relationships have not been established. The goals of this review are to: (1) summarize the biology of the NLRP3 inflammasome and its role in neuroinflammation, (2) evaluate evidence for NLRP3 dysregulation in schizophrenia and related neuropsychiatric disorders, (3) examine NLRP3 inhibitors tested in neuropsychiatric conditions and assess their translational relevance to schizophrenia, and (4) critically appraise the potential of NLRP3 as a peripheral and central biomarker of schizophrenia, identifying key gaps that future research must address.

Identifiers

PMID42587010

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.