Evidence map›Paper›PMID 42587157›Full record

ArticleNature2026

Procognitive restoration of PV neuron plasticity in neurodevelopmental disorders.

Yu-Tzu Shih, Jason Bondoc Alipio, Zin-Juan Klaft, Nathaniel Green, Alok Nath Mohapatra, Travis D Goode, Muthu Panchanatham, Devesh Pathak, Lai Ping Wong, Ruslan Sadreyev and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Yu-Tzu Shih *Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8266-8087
Jason Bondoc Alipio *Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Zin-Juan KlaftDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8208-7263
Nathaniel GreenCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Alok Nath MohapatraCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9994-6407
Travis D GoodeCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1432-8894
Muthu PanchanathamCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Devesh PathakCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Lai Ping WongDepartment of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ruslan SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jung Ho HyunDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.ORCID http://orcid.org/0000-0003-0185-5943
Omar AhmedDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3300-7658
Chris DullaDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6560-6535
Amar SahayCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA. asahay@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-0677-1693

Funding

Targeting neurogenesis-inhibition coupling to improve memory in aging\Diversity SupplementR01AG076612 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Amar Sahay · 2022 to 2026
$3.8M
Voltage Imaging of Astrocyte-Neuron InteractionsR01NS113499 · NINDS · TUFTS UNIVERSITY BOSTON · PI DULLA, CHRIS G · 2019 to 2023
$3.7M
Contributions of hippocampal oxytocin receptors to social recognitionR01MH111729 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SAHAY, AMAR · 2018 to 2022
$2.4M
Hippocampal synaptic and circuit mechanisms mediating Dyrk1a functions in social cognitionR01MH131652 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Amar Sahay · 2023 to 2026
$2.4M
Targeting Alternative Splicing of Sodium Channels to Treat Pediatric Developmental Epileptic EncephalopathiesR01NS139468 · NINDS · TUFTS UNIVERSITY MEDFORD · PI CHRISTOPHER B BURGE, Chris G Dulla · 2024 to 2026
$1.8M
NIA NIH HHS R01 AG076612NIMH NIH HHS R01 MH111729NIMH NIH HHS R01 MH131652NINDS NIH HHS R01 NS113499NINDS NIH HHS R01 NS139468
6 · The paper itself

Abstract

The hippocampus forms memories of our experiences in populations of coactive pyramidal neurons (PNs)

Identifiers

PMID42587157
PMCPMC13531005

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.