ReviewMacromolecular bioscience2026
Shape-Memory Injectable Cryogels: From Minimally Invasive Delivery to Multifunctional Tissue Regeneration.
Review in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Injectable cryogels have emerged as a transformative class of biomaterials that combine macroporosity, mechanical resilience, and shape-memory properties to enable minimally invasive therapeutic delivery. Unlike conventional hydrogels, cryogels are fabricated through cryogelation-a sub-zero polymerization process that generates interconnected macropores through ice crystal templating-endowing them with sponge-like elasticity and the ability to withstand extreme compression and recover their original architecture upon injection. Over the past decade, injectable cryogels have evolved from simple porous scaffolds to sophisticated multifunctional platforms incorporating nanocomposites, bioactive molecules, and stimuli-responsive elements for applications spanning bone and cartilage regeneration, stem cell delivery, cancer immunotherapy, and hemostatic wound healing. This review provides a comprehensive and critical analysis of recent advances in shape-memory injectable cryogels, organized around five interconnected themes: (i) the physicochemical mechanisms governing shape-memory behavior and material design strategies, (ii) emerging fabrication approaches including three-dimensional printing-cryogelation hybrids and nanocomposite reinforcement, (iii) cryogel-mediated stem cell delivery and tissue regeneration, (iv) immunomodulatory and vaccine platforms, and (v) hemostatic and wound-healing applications. We critically evaluate how macro-architectural features, mechanical tunability, and biochemical functionalization collectively dictate biological outcomes, and identify key challenges-including scalability, sterilization, regulatory pathways, and clinical translation-that must be addressed to realize the full therapeutic potential of injectable cryogels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.