Evidence map›Paper›PMID 42587351›Full record

ArticleBasic & clinical pharmacology & toxicology2026

Sex-Specific Relationships Between Nociceptin/Orphanin FQ Peptide (NOP) Receptors and Alcohol Drinking: Longitudinal PET Studies in Cynomolgus Monkeys.

Paul W Czoty, Kiran K Solingapuram Sai, Mack D Miller, Michael D Moore, Paul J Myburgh, Laura R Grace, Joshua N Prete, Phillip M Epperly

Abstract read
In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paul W CzotyDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0003-1778-4625
Kiran K Solingapuram SaiDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0002-6442-5169
Mack D MillerDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Michael D MooreDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0009-0009-0196-8527
Paul J MyburghDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0002-6760-607X
Laura R GraceDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Joshua N PreteDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Phillip M EpperlyDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Funding

NOP Receptors in nonhuman primate models of AUDR01AA027556 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CZOTY, PAUL W. · 2020 to 2024
$2.6M
NIAAA NIH HHS R01 AA027556
6 · The paper itself

Abstract

Drugs that interact with brain nociceptin/orphanin FQ (NOP) receptors can decrease ethanol consumption in preclinical models of alcohol use disorder (AUD). Studies using positron emission tomography (PET imaging) in humans with AUD reported lower levels of NOP receptors compared to controls. Here, uptake of the NOP receptor-selective PET radiotracer [

Indexed as

Alcohol DrinkingAlcoholismBrainReceptors, OpioidAnimalsDisease Models, AnimalEthanolFemaleLongitudinal StudiesMacaca fascicularisMaleNociceptin ReceptorPositron-Emission TomographySelf AdministrationSex FactorsEthanolNociceptin ReceptorReceptors, Opioid

Identifiers

PMID42587351
PMCPMC13469704

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.