Evidence map›Paper›PMID 42587736›Full record

ArticleCells2026

4-Phenylbutyrate Rescue in

Ziang Debbie Song, Kirill Zavalin, Wangzhen Shen, Melissa B DeLeeuw, Genevieve X Hunn, Ria S Eda, Li Ma, Juexin Wang, Jing-Qiong Kang

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ziang Debbie SongDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Kirill ZavalinDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-0094-3004
Wangzhen ShenDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Melissa B DeLeeuwDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-7700-016X
Genevieve X HunnDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Ria S EdaDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0009-0008-0636-2826
Li MaDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Juexin WangDepartment of Biomedical Engineering and Informatics, Luddy School of Informatics, Computing, and Engineering, Indiana University Indianapolis, Indianapolis, IN 46202, USA.ORCID 0000-0002-2260-4310
Jing-Qiong KangDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0003-1079-5436

Funding

Promoting Protein Trafficking with 4-phenylbutyrate to Treat Genetic EpilepsyR01NS121718 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jing-Qiong Kang · 2022 to 2026
$2.2M
Cure GABAA Variants N/ANINDS NIH HHS NS121718NINDS NIH HHS R01 NS121718
6 · The paper itself

Abstract

Disease variants in

Indexed as

EpilepsyPhenylbutyratesReceptors, GABA-AAnimalsDisease Models, AnimalHEK293 CellsHumansMiceMutation4-phenylbutyric acidGABRA1 protein, humanGabra1 protein, mousePhenylbutyratesReceptors, GABA-A4-phenylbutyrate (PBA)developmental and epileptic encephalopathy (DEE)GABAA receptorsGABRA1Gabra1 A322D knockin miceproteostasis

Identifiers

PMID42587736
PMCPMC13465587

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.