ReviewCells2026
Non-Coding RNAs in Vascular Calcification: Regulatory Networks, Functional Diversity, and Therapeutic Insights.
Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Vascular calcification is an ectopic calcium salt deposition process that lacks effective treatment under pathological conditions such as chronic kidney disease, diabetes, and aging. This review, for the first time, systematically categorizes miRNAs involved in the regulation of vascular calcification according to signaling pathways, clearly revealing the regulatory nodes and crosstalk among different pathways (Wnt/β catenin, BMP/Smad, NF κB, etc.), thereby providing a pathway-level theoretical basis for precision targeting. It also dissects the functional duality and microenvironment dependency of miRNAs-the same miRNA can exert opposite effects in different contexts, suggesting that miRNA-based drug development must focus on disease-selective targeted delivery to avoid the risk of functional reversal. This article further comprehensively summarizes the heterogeneous regulatory patterns of lncRNAs, the unique regulatory modes of circRNAs, and preliminary evidence suggesting the involvement of emerging non-coding RNAs (piRNAs, tsRNAs) and integrates the potential of circulating non-coding RNAs as non-invasive biomarkers and prospects for targeted therapeutic translation. This review provides a panoramic view of the network-based regulation of vascular calcification by non-coding RNAs, laying a theoretical foundation for precision diagnosis and multi-target combination intervention.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.