Evidence map›Paper›PMID 42587799›Full record

ReviewCells2026

Vaptans: A Narrative Review of Pharmacokinetics, Pharmacogenetics, and Clinical Applications.

Martyna Lica-Miler, Karol Miler, Dorota Kostrzewa-Nowak, Andrzej Ciechanowicz, Andrzej Brodkiewicz, Jacek Różański, Joanna Stępniewska

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Martyna Lica-MilerDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.ORCID 0009-0001-7651-8741
Karol MilerDepartment of Clinical and Molecular Biochemistry, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.ORCID 0009-0006-8320-0359
Dorota Kostrzewa-NowakDepartment of Clinical and Molecular Biochemistry, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.ORCID 0000-0001-7025-3087
Andrzej CiechanowiczDepartment of Clinical and Molecular Biochemistry, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.ORCID 0000-0002-3804-440X
Andrzej BrodkiewiczClinic of Pediatrics, Pediatric Nephrology, Dialysis and Treatment of Acute Poisoning, PUM Clinic in Szczecin at the "Zdroje" Hospital, ul. Maczna 4, 70-780 Szczecin, Poland.
Jacek RóżańskiDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Joanna StępniewskaDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.ORCID 0000-0002-0801-7582

Funding

Pomeranian Medical University
6 · The paper itself

Abstract

Vaptans are non-peptide arginine vasopressin (AVP) receptor antagonists essential for modulating water homeostasis. This review evaluates their chemical evolution from peptide analogs to orally bioavailable molecules and summarizes the pharmacokinetic profiles of key agents, including tolvaptan, conivaptan, and mozavaptan. Significant emphasis is placed on the clinical role of tolvaptan as a disease-modifying therapy in autosomal dominant polycystic kidney disease (ADPKD) and its efficacy in syndrome of inappropriate antidiuretic hormone secretion (SIADH). Furthermore, the impact of pharmacogenetic factors, especially

Indexed as

Antidiuretic Hormone Receptor AntagonistsPharmacogeneticsAnimalsHumansPolycystic Kidney, Autosomal DominantTolvaptanAntidiuretic Hormone Receptor AntagonistsTolvaptanADPKDpharmacogeneticspharmacokineticstolvaptanvaptans

Identifiers

PMID42587799
PMCPMC13464911

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.