ReviewCells2026
Current Status of Intestinal Stem Cell Research: Mechanisms, Intestinal Diseases, and Organoid Development.
Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Intestinal stem cells (ISCs) are essential for maintaining intestinal homeostasis and repairing injury, and have garnered extensive attention in recent years. ISC research has not only advanced our understanding of intestinal physiology but also revealed pathological roles of ISCs in diseases and facilitated the identification of potential targeted therapies. This review aims to comprehensively present the current state of ISC research. It elaborates on the multi-level regulatory mechanisms governing ISCs, including niche cells, signaling pathways, gut microbiota, extracellular matrix, and epigenetic regulation. It further summarizes the involvement of ISCs in colorectal cancer, inflammatory bowel disease, radiation-induced intestinal injury, and short bowel syndrome, as well as their application in organoid technology. Finally, this review highlights future directions, including dissecting how distinct cellular states and microenvironments dynamically regulate ISC function, and the integration of cutting-edge technologies like microfluidic organ-on-a-chip and gene editing technologies to accelerate the translation of basic discoveries into clinical practice, thereby providing a valuable reference for researchers in the field.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.