Food-Derived Zinc-Chelating Peptides: Coordination Chemistry, Intestinal Transport, and Nutritional Functionality.

Lanshi Tian, Shan Yang, Peng Li, Jinzi Yin, Jia Zhou, Zhongmei He

Abstract readReview

In one paragraph

Review in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lanshi TianCollege of Traditional Chinese Medicines, Jilin Agricultural University, No. 2888, Xincheng Street, Changchun 130118, China.

Shan YangCollege of Traditional Chinese Medicines, Jilin Agricultural University, No. 2888, Xincheng Street, Changchun 130118, China.

Peng LiCollege of Traditional Chinese Medicines, Jilin Agricultural University, No. 2888, Xincheng Street, Changchun 130118, China.

Jinzi YinCollege of Traditional Chinese Medicines, Jilin Agricultural University, No. 2888, Xincheng Street, Changchun 130118, China.

Jia ZhouCollege of Traditional Chinese Medicines, Jilin Agricultural University, No. 2888, Xincheng Street, Changchun 130118, China.

Zhongmei HeCollege of Traditional Chinese Medicines, Jilin Agricultural University, No. 2888, Xincheng Street, Changchun 130118, China.ORCID 0000-0002-2694-6510

Funding

Changchun Key Research and Development Program Key Project-Research, Development, and Application Promotion of the Full Industrial Chain for Sika Deer 2025ZDYFNS06Establishment of Key Laboratories for International Scientific and Technological Cooperation in Jilin Province: Jilin Provincial Key Laboratory for International Cooperation on Efficient Breeding and Product Development of Sika Deer YDZJ202502CXJD077Jilin Science and Technology Development Talent Special Project: Study on the key technology and industrialization of chelating calcium from deer tendon under grant 20240601086RCThe development and industrialization of health food Rongshen Yizhi tablets to assist in improving learning and memory function YDZJ202603CGZH013

6 · The paper itself

Abstract

Food-derived zinc-chelating peptides (ZCPs) have emerged as promising nutritional carriers that enhance zinc bioavailability and exert diverse biological activities. Compared with conventional zinc supplements, peptide-mediated zinc delivery systems exhibit superior gastrointestinal stability, reduced mineral precipitation, and improved intestinal transport efficiency. The present study demonstrates that ZCPs regulate zinc homeostasis through multiple mechanisms, including coordination chemistry, transporter-mediated absorption, regulation of the epithelial barrier, and interactions with the intestinal microenvironment. Beyond facilitating zinc absorption, peptide-zinc complexes exhibit antioxidant, anti-inflammatory, immunomodulatory, metabolic regulatory, and gut-protective activities through the synergistic effects of coordinated zinc ions and peptide bioactivity. Advances in spectroscopic characterization, computational modeling, and systems nutrition approaches have further expanded current understanding of peptide-zinc coordination behavior and physiological functionality. Nevertheless, current studies remain limited by insufficient clinical validation and an incomplete understanding of intestinal transport kinetics and controlled zinc release mechanisms. Overall, food-derived ZCPs demonstrate considerable potential for precision nutrition interventions and the development of next-generation functional zinc delivery systems.

Indexed as

Chelating AgentsIntestinal AbsorptionPeptidesZincAnimalsBioactive Peptides, DietaryBiological AvailabilityBiological TransportHomeostasisHumansIntestinal Barrier FunctionIntestinal MucosaBioactive Peptides, DietaryChelating AgentsPeptidesZincfood-derived peptidesintestinal transportprecision nutritionzinc-chelating peptideszinc homeostasis

Identifiers

PMID42588032

DOI10.3390/nu18152409

PMCPMC13468562

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.