Evidence map›Paper›PMID 42588187›Full record

ArticleNutrients2026

Wenhao Hao, Yuxin Zhao, Huimin Cui, Andong Liu, Wei Gong, Kangling Wang, Hong Lin, Lei Hao, Fanfan Han, Jianjun Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenhao HaoSchool of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Yuxin ZhaoSchool of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Huimin CuiSchool of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Andong LiuSchool of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Wei GongSchool of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Kangling WangSchool of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Hong LinSchool of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Lei HaoDepartment of Allied and Public Health, Indiana University of Pennsylvania, Indiana, PA 15705, USA.
Fanfan HanSchool of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Jianjun YangSchool of Public Health, Ningxia Medical University, Yinchuan 750004, China.

Funding

National Natural Science Foundation of China 2023AAC02041National Natural Science Foundation of China 82560643Ningxia Medical University XJKF250424
6 · The paper itself

Abstract

backgroundNon-invasive therapies for heart failure represent one of the current major focuses in clinical research. Plant-derived extracellular vesicles (PEVs) have recently emerged as a promising therapeutic modality.

objectivesIn this study, we investigated the therapeutic potential of PEVs in heart failure with preserved ejection fraction (HFpEF), focusing on extracellular vesicles derived from

methodsWe first obtained Gq-EVs with high biological activity and high concentration from

resultsOur in vivo findings indicate that nebulized inhalation of Gq-EVs for 7, 14, and 21 days improved abnormal cardiac diastolic function, reduced excessive myocardial hypertrophy, and attenuated inflammatory cell infiltration and collagen deposition in HFpEF mice. Further in vivo and in vitro experiments showed that Gq-EVs can reach injured cardiac tissue, improve mitochondrial function, and are associated with reduced cardiomyocyte apoptosis and amelioration of myocardial hypertrophy, potentially involving

conclusionsOverall, nebulized delivery of Gq-EVs may be a relatively non-invasive, well-tolerated, and cost-effective therapeutic strategy for HFpEF, highlighting the potential of PEV-based nanotherapies and offering a sustainable approach for the medical utilization of

Indexed as

ApoptosisCardiomegalyExtracellular VesiclesHeart FailureLyciumMyocytes, CardiacStroke VolumeAnimalsDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLTumor Suppressor Protein p53Tumor Suppressor Protein p53apoptosisheart failure with preserved ejection fractionLycium barbarum-derived extracellular vesiclesmitochondrial functionmyocardial hypertrophyTP53

Identifiers

PMID42588187
PMCPMC13468228

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.