Evidence map›Paper›PMID 42588448›Full record

ArticleMolecules (Basel, Switzerland)2026

Interfacial and Molecular Mechanisms of Pancreatic Lipase Modulation by Saponin-Rich Extracts with Antioxidant Activity.

Zbigniew Sroka, Karina Kapusta, Senal D Liyanage, Ta'Miyia Tobias, Victoria Petrosyan, Wojciech Kolodziejczyk, Karolina Imiełowska, Michał Gleńsk, Beata Żbikowska, Andrzej Gamian and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zbigniew SrokaDepartment of Pharmacognosy and Herbal Medicines, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.ORCID 0000-0001-6618-017X
Karina KapustaDepartment of Chemistry, Physics and Atmospheric Sciences, Jackson State University, Jackson, MS 39217, USA.ORCID 0000-0001-8466-4098
Senal D LiyanageDepartment of Chemistry and Physics, Tougaloo College, Tougaloo, MS 39174, USA.ORCID 0000-0002-9166-0527
Ta'Miyia TobiasDepartment of Chemistry and Physics, Tougaloo College, Tougaloo, MS 39174, USA.ORCID 0009-0000-5169-7192
Victoria PetrosyanDepartment of Chemistry and Physics, Tougaloo College, Tougaloo, MS 39174, USA.ORCID 0009-0007-0276-7968
Wojciech KolodziejczykDepartment of Chemistry, Physics and Atmospheric Sciences, Jackson State University, Jackson, MS 39217, USA.ORCID 0000-0002-7754-8969
Karolina ImiełowskaFaculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Michał GleńskDepartment of Pharmacognosy and Herbal Medicines, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.
Beata ŻbikowskaDepartment of Pharmacognosy and Herbal Medicines, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.
Andrzej GamianDepartment of Immunology of Infectious Diseases, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland.ORCID 0000-0002-2206-6591
Kamil WojciechowskiDepartment of Chemistry, University of Warmia and Mazury in Olsztyn, 10-721 Olsztyn, Poland.ORCID 0000-0001-7693-9469

Funding

Ludwik Hirszfeld Institute of Immunology and Experimental Therapy PAS 501-15National Science Centre 2025/57/B/ST4/01341U.S. National Science Foundation OIA-2414445 and 2510537Wroclaw Medical University SUBZ.D110.26.002
6 · The paper itself

Abstract

Pancreatic lipase activity depends strongly on interfacial conditions created by bile salts, motivating the search for plant-derived surfactants that may modulate lipid digestion. In our previous work, ginseng root and horse chestnut seed extracts were identified as potent stimulators of pancreatic lipase. Here, we expanded this investigation to additional

Indexed as

AntioxidantsLipasePancreasPlant ExtractsSaponinsAesculusAnimalsLipolysisPanaxAntioxidantsLipasePlant ExtractsSaponinsAesculus hippocastanumbile salt substitutesinterfacial activitylipid digestionmolecular dynamicsmolecular modelingPanax ginsengpancreatic lipasesaponin-rich plant extractssurface rheology

Identifiers

PMID42588448
PMCPMC13468043

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.