Evidence map›Paper›PMID 42588556›Full record

ReviewMolecules (Basel, Switzerland)2026

Transformation of Agro-Industrial By-Products into High-Value Animal-Derived Foods: Bioactive Compounds, Microbiome-Mediated Biotransformation, Metabolomic Traceability and Circular Valorization.

Lucrezia Forte, Eric N Ponnampalam, Pasquale De Palo, Edyta Kowalczuk-Vasilev, John Quiñones, Abdelfattah Z M Salem, Aristide Maggiolino

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lucrezia ForteDepartment of Veterinary Medicine, University of Bari Aldo Moro, Strada Provinciale per Casamassima Km 3, Valenzano, 70010 Bari, Italy.ORCID 0009-0004-3523-9078
Eric N PonnampalamSchool of Agriculture, Food and Ecosystems Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.
Pasquale De PaloDepartment of Veterinary Medicine, University of Bari Aldo Moro, Strada Provinciale per Casamassima Km 3, Valenzano, 70010 Bari, Italy.ORCID 0000-0002-5612-1691
Edyta Kowalczuk-VasilevInstitute of Animal Nutrition and Bromatology, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, 20-950 Lublin, Poland.
John QuiñonesMeat Quality Innovation and Technology Centre (CTI-Carne), Universidad de La Frontera, Temuco 4780000, Chile.ORCID 0000-0002-5353-3084
Abdelfattah Z M SalemDepartment of Soil, Plant, and Food, University of Bari Aldo Moro, Via Giovanni Amendola, 165/a, 70126 Bari, Italy.ORCID 0000-0001-7418-4170
Aristide MaggiolinoDepartment of Veterinary Medicine, University of Bari Aldo Moro, Strada Provinciale per Casamassima Km 3, Valenzano, 70010 Bari, Italy.ORCID 0000-0001-7128-8556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Agro-industrial by-products are increasingly considered as feed resources for circular animal production, but their value should not be interpreted only as a low-cost replacement of conventional ingredients. This scoping review critically examines how by-products from grape, olive, tomato, citrus, cereal, brewery, oilseed and vegetable processing chains may contribute to the development of high-value animal-derived foods. Particular attention is given to bioactive compounds, polyphenols, carotenoids, tocopherols, fermentable fibres and residual lipids, as well as to microbiome-mediated biotransformation, host metabolic pathways, compound transfer, product-quality modulation, feed safety and circular valorization. Available evidence indicates that selected by-products can influence milk, cheese, meat, eggs and fish products by modifying fatty acid profile, oxidative stability, antioxidant-related traits, pigmentation, volatile compounds, shelf-life and, in some cases, the transfer of specific metabolites to edible products. However, these responses depend on by-product source, processing method, inclusion level, active dose, animal species, basal diet and analytical endpoints. Chemical richness alone is therefore insufficient to support functional claims. Stronger evidence requires studies that connect matrix characterization, processing stability, microbial and host-mediated transformation, biological intermediates and final product quality within the same experimental design. Precision circular feeding should therefore combine local availability, safety, active-dose definition, metabolomic and lipidomic traceability, and product-level validation to support reproducible improvements in high-value animal-derived foods.

Indexed as

Animal FeedMetabolomicsMicrobiotaAnimalsBiotransformationPolyphenolsPolyphenolscircular bioeconomyfeed valorizationfoodomicsgut microbiotalipid oxidationmetabolite transferpolyphenolsproduct quality

Identifiers

PMID42588556
PMCPMC13467954

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.