Evidence map›Paper›PMID 42588646›Full record

ArticleCancers2026

Rare Germline Variants in Key Pathways Contribute to Hepatocellular Carcinoma Risk in Hispanic Individuals.

Xiangnan Li, Yanhong Liu, Spiridon Tsavachidis, Priya B Shetty, Amit G Singal, Ruben Hernaez, Sumeet K Asrani, Saira Khaderi, Hashem B El-Serag, Aaron P Thrift

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiangnan LiSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3789-2861
Yanhong LiuSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-6747-6834
Spiridon TsavachidisSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Priya B ShettySection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-2086-3319
Amit G SingalDivision of Digestive and Liver Diseases, Department of Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Ruben HernaezSection of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Sumeet K AsraniDivision of Hepatology, Baylor University Medical Center, Dallas, TX 75246, USA.
Saira KhaderiSection of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Hashem B El-SeragSection of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Aaron P ThriftSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-0084-5308

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Prevention of Hepatocellular Carcinoma Related to Metabolic SyndromeP01CA263025 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Christopher I. Amos · 2022 to 2026
$8.9M
UT Southwestern Liver Cancer SPOREP50CA295495 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Amit Singal · 2025 to 2026
$7.5M
Risk Stratification for and Early Detection of Liver CancerU01CA230997 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Jagpreet Chhatwal, Hashem B El-Serag · 2018 to 2026
$6.4M
Clinical Validation Center for Hepatocellular CarcinomaU01CA271887 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI FASIHA KANWAL, JORGE A MARRERO · 2022 to 2026
$4.7M
Precision Risk Stratification and Screening for HCC among Patients with Indeterminate Liver NodulesU01CA283935 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HOSHIDA, YUJIN, SINGAL, AMIT · 2023 to 2025
$3.9M
Cancer Prevention and Research Institute of Texas RP150587Cancer Prevention and Research Institute of Texas RP200537Cancer Prevention and Research Institute of Texas RP200554Cancer Prevention and Research Institute of Texas RP220119Cancer Prevention and Research Institute of Texas RP250355Cancer Prevention and Research Institute of Texas RR210027NCI NIH HHS NCI P01 CA263025NCI NIH HHS NCI P50 CA295495NCI NIH HHS NCI U01 CA230997NCI NIH HHS NCI U01 CA271887NCI NIH HHS NCI U01 CA283935NCI NIH HHS P01 CA263025NCI NIH HHS P50 CA295495NCI NIH HHS U01 CA230997NCI NIH HHS U01 CA271887NCI NIH HHS U01 CA283935NIDDK NIH HHS NIDDK P30 DK56338NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

genetic susceptibilityhepatocellular carcinomaHispanicrare variant

Identifiers

PMID42588646
PMCPMC13464447

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.