Evidence map›Paper›PMID 42588912›Full record

ReviewPlants (Basel, Switzerland)2026

African Polyherbal Formulations for Type 2 Diabetes: A Systematic Review and Meta-Analysis of Efficacy, Mechanisms, and Therapeutic Potential.

Nokukhanya Thembane, Siphamandla Hlatshwayo, Sanele Nobleman Mhlungu, Siboniso Percival Sithole, Phikelelani Ngubane, Mlungisi Ngcobo, Nceba Gqaleni

Abstract readReview
In one paragraph

Review in Plants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nokukhanya ThembaneDepartment of Biomedical Sciences, Faculty of Applied and Health Sciences, Mangosuthu University of Technology, Durban 4026, South Africa.ORCID 0000-0002-3242-6159
Siphamandla HlatshwayoSub-Discipline of Traditional Medicine, School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.ORCID 0000-0002-2655-5341
Sanele Nobleman MhlunguSub-Discipline of Traditional Medicine, School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.ORCID 0000-0002-9670-4648
Siboniso Percival SitholeSub-Discipline of Traditional Medicine, School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.ORCID 0000-0002-6290-6559
Phikelelani NgubaneSub-Discipline of Traditional Medicine, School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.
Mlungisi NgcoboSub-Discipline of Traditional Medicine, School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.ORCID 0000-0001-8942-1642
Nceba GqaleniSub-Discipline of Traditional Medicine, School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes (T2D) remains a major public health challenge in Africa, where limited healthcare access and the high cost of conventional therapies sustain reliance on African traditional medicine (ATM). This systematic review and meta-analysis evaluated the efficacy, mechanisms of action, and safety of African polyherbal formulations for T2D management. This systematic review and meta-analysis was conducted in accordance with PRISMA 2020 guidelines, following a protocol registered with PROSPERO (CRD420251168831). We searched PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar for studies published between 1 January 2011 and 31 December 2024. Seventeen studies met the inclusion criteria. Polyherbal formulations consistently improved glycaemic control, insulin sensitivity, antioxidant status, and lipid profiles. Meta-analysis of 10 preclinical studies demonstrated a significant reduction in fasting blood glucose compared with that of diabetic controls (SMD = -5.22, 95% CI: -5.55 to -4.89;

Indexed as

African traditional medicineantidiabetic activitybioactive phytochemicalsphytochemical profilingpolyherbal formulationspolyherbal interactionsType 2 diabetes

Identifiers

PMID42588912
PMCPMC13468302

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.