Evidence map›Paper›PMID 42589086›Full record

ArticleBiology2026

SELENOT, a Key Membrane-Bound Selenoprotein, Mediates Selenium's Protection Against Lead-Induced Renal Aging in Chickens by Modulating Inflammation and Autophagy.

Yan Wang, Zhiyu Hao, Minna Qiu, Minghang Chang, Xiumei Liu, Yihao Zhu, Hao Wang, Shi Li, Yuhao Liu, Xiaohua Teng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan WangSchool of Public Health, Beihua University, Jilin 132013, China.
Zhiyu HaoCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Minna QiuCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Minghang ChangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Xiumei LiuCollege of Life Sciences, Yantai University, Yantai 264005, China.
Yihao ZhuHeilongjiang Animal Husbandry Service, Harbin 150069, China.
Hao WangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Shi LiCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Yuhao LiuCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Xiaohua TengCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.ORCID 0000-0003-0912-3325
You TangElectrical and Information Engineering College, Jilin Agricultural Science and Technology University, Jilin 132101, China.

Funding

Science and Technology Development Plan Project of Jilin Province YDZJ202501ZYTS805Science and Technology Research Project of the Jilin Provincial Department of Education JJKH20250832KJ
6 · The paper itself

Abstract

Lead (Pb) pollution is a global public health issue, yet the mechanisms underlying Pb-induced kidney aging remain poorly understood. Selenium (Se), an essential trace element critical for kidney health, primarily exerts its physiological roles via selenoproteins; among them, membrane-bound selenoproteins strategically localized at the endoplasmic reticulum and plasma membrane, have emerged as potential molecular links in Se-mediated protection. In this study, Hyline chicken models (treated with 350.00 mg/L Pb or/and 1.00 mg/kg Se) and HK-2 cell models (treated with 200 μM Pb or/and 2.5 μM Se) were established to investigate the protective mechanism of Se to Pb poisoning in kidneys, with emphasis on membrane-bound selenoproteins and kidney aging. Results showed that Pb significantly decreased (

Indexed as

autophagyinflammationkidney agingleadmembrane-bound selenoproteinsselenium

Identifiers

PMID42589086
PMCPMC13463916

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.