ArticleBiology2026
Nasopharyngeal Microbiome Differences Between Children with Hypertrophic Adenoids and Healthy Controls.
Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundAdenoids play a pivotal role in immune system maturation during early childhood; however, pathological adenoid hypertrophy is associated with significant morbidity. Although infectious and immunological factors have been implicated, the role of the nasopharyngeal microbiome in adenoid hypertrophy remains incompletely understood.
methodsIn this cross-sectional study, the nasopharyngeal microbiome of 26 children diagnosed with symptomatic hypertrophic adenoids was compared with that of 30 age-matched healthy controls with non-hypertrophic adenoids. Microbial profiling was performed using 16S rRNA (ribosomal ribonucleic acid)gene sequencing. Alpha and beta diversity, core microbiome, network and differential abundance analyses were performed.
resultsAlpha diversity showed significant group differences (Fisher's alpha
conclusionsWhen compared with healthy controls, children with symptomatic hypertrophic adenoids exhibit a distinct nasopharyngeal microbiome characterized by altered microbial community structure and shifts in specific bacterial taxa. These findings support a potential role of the microbiome in the pathogenesis of adenoid hypertrophy.
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