Evidence map›Paper›PMID 42589144›Full record

ArticleBiology2026

Establishment of a Keratin 14/17-Induced Antigen-Specific Psoriasis-like Mouse Model.

Lanying Wang, Yulu Tang, Wenjing Li, Pengcheng Zhu, Wenjing Jia, Hao Liu, Yuanfang Ma, Guimei Wang, Ruiling Liu, Qingguo Ruan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lanying WangJoint National Laboratory for Antibody Drug Engineering, School of Synthetic Biology and Pharmaceutical Engineering, Henan University, Kaifeng 475004, China.
Yulu TangJoint National Laboratory for Antibody Drug Engineering, School of Synthetic Biology and Pharmaceutical Engineering, Henan University, Kaifeng 475004, China.
Wenjing LiJoint National Laboratory for Antibody Drug Engineering, School of Synthetic Biology and Pharmaceutical Engineering, Henan University, Kaifeng 475004, China.
Pengcheng ZhuJoint National Laboratory for Antibody Drug Engineering, School of Synthetic Biology and Pharmaceutical Engineering, Henan University, Kaifeng 475004, China.
Wenjing JiaJoint National Laboratory for Antibody Drug Engineering, School of Synthetic Biology and Pharmaceutical Engineering, Henan University, Kaifeng 475004, China.
Hao LiuJoint National Laboratory for Antibody Drug Engineering, School of Synthetic Biology and Pharmaceutical Engineering, Henan University, Kaifeng 475004, China.
Yuanfang MaJoint National Laboratory for Antibody Drug Engineering, School of Synthetic Biology and Pharmaceutical Engineering, Henan University, Kaifeng 475004, China.
Guimei WangJoint National Laboratory for Antibody Drug Engineering, School of Synthetic Biology and Pharmaceutical Engineering, Henan University, Kaifeng 475004, China.
Ruiling LiuJoint National Laboratory for Antibody Drug Engineering, School of Synthetic Biology and Pharmaceutical Engineering, Henan University, Kaifeng 475004, China.
Qingguo RuanJoint National Laboratory for Antibody Drug Engineering, School of Synthetic Biology and Pharmaceutical Engineering, Henan University, Kaifeng 475004, China.ORCID 0000-0001-9315-3716
Shijun J ZhengJoint National Laboratory for Antibody Drug Engineering, School of Synthetic Biology and Pharmaceutical Engineering, Henan University, Kaifeng 475004, China.ORCID 0000-0001-9462-4794

Funding

Foundation of Henan educational committee 25A310001Henan University CX3050A1000178Henan University CX3050A1000179Henan University CX3050A1000180National Natural Science Foundation of China 82271129National Natural Science Foundation of China 82471063Natural Science Foundation of Henan Province 252300421378
6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory autoimmune skin disease significantly impairing the patients' quality of life. Keratin (K)14 and K17 are abnormally expressed in psoriasis patients and considered to be potential autoantigens triggering this disease. However, the animal model for psoriasis induced with a specific antigen is yet to be established. Here we show that vaccinating BALB/c and C57BL/6J mice with purified murine recombinant K14 or K17 antigen induced psoriasis-like clinical symptoms in 40 ± 30% of animals, such as erythema and scaling, accompanied by hallmark histopathological changes including significant epidermal hyperplasia and inflammatory cell infiltration in the lesions. Furthermore, the immunized mice produced high levels of specific antibodies against K14/K17 in the blood, along with antigen-specific T-cell responses. These data indicate that immunization of mice with K14 and K17 antigens could cause psoriasis-like symptoms with immunopathological features of psoriasis, providing a novel experimental animal model for investigating the pathogenesis of psoriasis and development of effective therapies.

Indexed as

autoantigenkeratin 14keratin 17mouse modelpsoriasis

Identifiers

PMID42589144
PMCPMC13464592

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.