Evidence map›Paper›PMID 42589157›Full record

ArticleBiology2026

Sonic Hedgehog Signaling Promotes Survival and Lineage Specific Differentiation of Transplanted Neural Precursor Cells and Improves Motor Recovery After Thoracic Spinal Cord Injury in Rats.

Mohamed Tail, Guoli Zheng, Hao Zhang, Hao Wang, Anna-Kathrin Harms, Maryam Hatami, Thomas Skutella, Andreas Unterberg, Klaus Zweckberger, Alexander Younsi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohamed TailDepartment of Neurosurgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Guoli ZhengDepartment of Neurosurgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-7875-6006
Hao ZhangDepartment of Neurosurgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Hao WangDepartment of Neurosurgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Anna-Kathrin HarmsDepartment of Neurosurgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Maryam HatamiMedical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.
Thomas SkutellaMedical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-4813-1213
Andreas UnterbergDepartment of Neurosurgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Klaus ZweckbergerDepartment of Neurosurgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Alexander YounsiDepartment of Neurosurgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-8218-9243

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transplanted neural precursor cells (NPCs) can support repair after spinal cord injury (SCI) but often face poor survival and limited differentiation within the hostile post-injury microenvironment. We tested whether subacute activation of Sonic hedgehog (Shh) signaling improves NPC engraftment and functional recovery over the duration of 6 weeks. Female Wistar rats underwent T9/T10 clip-contusion SCI and were assigned to vehicle, Shh-only, NPC-only, Shh + NPC, or sham groups (

Indexed as

neural precursor cellsneuroinflammationneuroregenerationsonic hedgehogspinal cord injury

Identifiers

PMID42589157
PMCPMC13464973

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.