Evidence mapPaperPMID 42589221Full record

ArticleInternational journal of molecular sciences2026

Amphiphilic Semisynthetic Triterpenoids Impair Survival Pathways and Suppress Clonogenic Growth in Multidrug-Resistant High-Risk Neuroblastoma.

Silvana Alfei, Cinzia Domenicotti, Sara Tirendi, Elaheh Khaledizadeh, Dafni Graikioti, Constantinos M Athanassopoulos, Guendalina Zuccari, Caterina Reggio, Barbara Marengo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Silvana AlfeiDepartment of Pharmacy, University of Genoa, Viale Cembrano, 16148 Genoa, Italy.ORCID 0000-0002-4630-4371
Cinzia DomenicottiDepartment of Experimental Medicine (DIMES), University of Genova, Via Alberti L.B., 16132 Genoa, Italy.ORCID 0000-0002-5003-7333
Sara TirendiDepartment of Experimental Medicine (DIMES), University of Genova, Via Alberti L.B., 16132 Genoa, Italy.ORCID 0000-0003-2384-0072
Elaheh KhaledizadehDepartment of Experimental Medicine (DIMES), University of Genova, Via Alberti L.B., 16132 Genoa, Italy.ORCID 0009-0003-7390-916X
Dafni GraikiotiDepartment of Chemistry, University of Patras, University Campus Rio Achaias, 26504 Rio, Greece.ORCID 0000-0001-8057-0019
Constantinos M AthanassopoulosDepartment of Chemistry, University of Patras, University Campus Rio Achaias, 26504 Rio, Greece.ORCID 0000-0002-7549-1911
Guendalina ZuccariDepartment of Pharmacy, University of Genoa, Viale Cembrano, 16148 Genoa, Italy.ORCID 0000-0002-9868-6199
Caterina ReggioLaboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147 Genoa, Italy.
Barbara MarengoDepartment of Experimental Medicine (DIMES), University of Genova, Via Alberti L.B., 16132 Genoa, Italy.ORCID 0000-0003-3056-6569

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-risk neuroblastoma (HR-NB) remains a major clinical challenge due to the emergence of therapy resistance. In this study, the anticancer effects of seven previously synthesized betulin (BET), betulinic acid (BA) and ursolic acid (UA) derivatives (

Indexed as

Antineoplastic AgentsDrug Resistance, MultipleDrug Resistance, NeoplasmNeuroblastomaTriterpenesApoptosisBetulinic AcidCell Line, TumorCell ProliferationCell SurvivalHumansPentacyclic TriterpenesUrsolic AcidAntineoplastic AgentsBetulinic AcidPentacyclic TriterpenesTriterpenesUrsolic AcidAkt and ERK1/2 kinase systemcell viabilityclonogenicityhigh-risk NB (HR-NB)nanovesiclesnatural triterpenoidssynthetic triterpenes

Identifiers

PMID42589221
PMCPMC13466524

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.