Evidence map›Paper›PMID 42589222›Full record

ArticleInternational journal of molecular sciences2026

Nrf2 Deficiency Exacerbates Methamphetamine-Induced Neuronal Apoptosis and Cognitive Dysfunction in Male Mice.

Qianyun Nie, Wenjuan Dong, Peng Zhang, Genmeng Yang, Di Jing, Zhenping Hou, Yanxia Peng, Yang Yu, Lihua Li, Shijun Hong

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qianyun NieNational Health Commission (NHC) Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
Wenjuan DongNational Health Commission (NHC) Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
Peng ZhangKey Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou 571199, China.
Genmeng YangNational Health Commission (NHC) Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
Di JingNational Health Commission (NHC) Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
Zhenping HouNational Health Commission (NHC) Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
Yanxia PengNational Health Commission (NHC) Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
Yang YuNational Health Commission (NHC) Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
Lihua LiNational Health Commission (NHC) Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
Shijun HongNational Health Commission (NHC) Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.ORCID 0000-0002-3186-734X

Funding

Academic Enhancement Support Program of Hainan Medical University XSTS2026192Education Department of Hainan Province Hnky2024-32Joint Research Project of Science and Technology Department of Yunnan Province & Kunming Medical University 202301AY070001-026Kunming Medical University 2020DAMARC-002National Natural Science Foundation of China 82260336, 82371898Undergraduate Scientific Research and Innovation Training Program of Hainan Medical University, China RZ2500002193
6 · The paper itself

Abstract

Methamphetamine (MA) abuse, a growing global public health concern, has been linked to the emergence of neuropsychiatric effects, largely attributed to MA-induced neurotoxicity. Despite its significant impact, the precise mechanisms underlying this neurotoxicity remain poorly understood, and current therapeutic options for MA abusing patients are limited. In the present study, primary mouse neurons with 400 μM MA treatment and

Indexed as

ApoptosisCognitive DysfunctionMethamphetamineNeuronsNF-E2-Related Factor 2AnimalsHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitochondrial DynamicsMitophagyOxidative StressPrefrontal CortexMethamphetamineNfe2l2 protein, mouseNF-E2-Related Factor 2parkin proteinPTEN-Induced Putative KinaseUbiquitin-Protein Ligasesmethamphetaminemitochondrial dynamicsmitophagyneurotoxic damageNrf2

Identifiers

PMID42589222
PMCPMC13465678

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.