Evidence map›Paper›PMID 42589249›Full record

ArticleInternational journal of molecular sciences2026

Extracellular Vesicle Phenotypic Trajectories During Alcohol Withdrawal Treatment.

Vsevolod V Severtsev, Alexander A Yakovlev, Alexey S Golovkin, Arthur D Aquino, Adrian A Zavodov, Vasiliy S Chernyshev, Maria A Vinnikova, Yuliya G Tikhonova, Milausha Sh Galeeva, Marina A Kinkulkina and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vsevolod V SevertsevDepartment of Psychiatry and Narcology, N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov University, 119048 Moscow, Russia.ORCID 0000-0001-8712-3561
Alexander A YakovlevLaboratory of Cellular Neurobiology of Learning, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.ORCID 0000-0003-2546-5130
Alexey S GolovkinLaboratory of Microvesicular Signaling, Institute of Molecular Biology and Genetics, Almazov National Medical Research Center, 197341 St. Petersburg, Russia.ORCID 0000-0002-7577-628X
Arthur D AquinoLaboratory of Microvesicular Signaling, Institute of Molecular Biology and Genetics, Almazov National Medical Research Center, 197341 St. Petersburg, Russia.ORCID 0000-0001-6516-7184
Adrian A ZavodovSkolkovo Innovation Center, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia.ORCID 0000-0003-1954-2398
Vasiliy S ChernyshevSkolkovo Innovation Center, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia.ORCID 0000-0003-2372-7037
Maria A VinnikovaDepartment of Psychiatry and Narcology, N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov University, 119048 Moscow, Russia.
Yuliya G TikhonovaDepartment of Psychiatry and Narcology, N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov University, 119048 Moscow, Russia.ORCID 0000-0001-6071-2796
Milausha Sh GaleevaDepartment of Psychiatry and Narcology, N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov University, 119048 Moscow, Russia.
Marina A KinkulkinaDepartment of Psychiatry and Narcology, N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov University, 119048 Moscow, Russia.
Nikolay N IvanetsDepartment of Psychiatry and Narcology, N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov University, 119048 Moscow, Russia.

Funding

Russian Science Foundation 25-75-00120
6 · The paper itself

Abstract

Alcohol dependence or alcohol use disorder is a chronic mental disorder that imposes a heavy global burden. Small extracellular vesicles (EVs) are emerging as a promising source of real-time information about brain status, yet existing studies are predominantly cross-sectional. We aimed to characterize longitudinal changes in EV properties and immunophenotype during alcohol withdrawal treatment. In our study plasma-derived EVs were analyzed and immunophenotyping via flow cytometry was performed to measure the concentrations of vesicle fractions carrying erythrocyte-, platelet-, endothelial-, and neuronal-associated markers in patients undergoing alcohol withdrawal and in healthy volunteers. Patient-derived EVs exhibited greater size heterogeneity, and microscopy images revealed vesicles with altered morphology. Concentrations of EVs bearing NLGN3 were lower in patients. CD62P+ and CD146+ EVs were also less represented in patients. Notably, CD31+ EVs separated into two distinct clusters; their concentrations were higher in patients with a binge drinking pattern but markedly lower in those with a steady pattern. The findings reveal dynamic phenotypic shifts in circulating EVs during alcohol withdrawal. The divergent patterns according to alcohol use history highlight the potential of EV profiling for personalized monitoring and underscore the necessity of longitudinal designs in vesicle-based biomarker research.

Indexed as

AlcoholismExtracellular VesiclesSubstance Withdrawal SyndromeAdultBiomarkersFemaleHumansImmunophenotypingMaleMiddle AgedPhenotypeBiomarkersalcohol withdrawal syndromeextracellular vesiclestemporal dynamicsvesicle morphologyvesicle phenotypes

Identifiers

PMID42589249
PMCPMC13466336

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.