Evidence map›Paper›PMID 42589300›Full record

ArticleInternational journal of molecular sciences2026

2-(Arylamino)thiazol-4(5H)-ones Mitigate Oxidative Stress and Confer Neuroprotection in Cellular and

Nikhil Raj Selvaraj, Bhuvaneshwari S V, Durga Nandan, Sandra San, Sudarslal Sadasivan Nair, Bipin G Nair, Parvathy Venugopal, Rajaguru Aradhya, Vipin A Nair

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nikhil Raj SelvarajSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, India.
Bhuvaneshwari S VDepartment of Chemistry, REVA University, Kattigenahalli, Yelahanka, Bangalore 560064, India.
Durga NandanSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, India.ORCID 0009-0002-6477-5465
Sandra SanSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, India.
Sudarslal Sadasivan NairSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, India.ORCID 0000-0001-7341-4974
Bipin G NairSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, India.
Parvathy VenugopalSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, India.
Rajaguru AradhyaSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, India.
Vipin A NairSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disorder with limited effective therapies. In this study, a series of 2-(arylamino)thiazol-4(5H)-one derivatives was synthesized using an efficient microwave-assisted protocol, and evaluated for neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress (OS) in SH-SY5Y neuronal cells and an Aβ42-expressing

Indexed as

Alzheimer DiseaseNeuroprotectionNeuroprotective AgentsOxidative StressThiazolesAcetylcholinesteraseAmyloid beta-PeptidesAnimalsCell Line, TumorCell SurvivalCholinesterase InhibitorsDisease Models, AnimalDrosophila melanogasterHumansMembrane Potential, MitochondrialMolecular Docking SimulationAcetylcholinesteraseAmyloid beta-PeptidesCholinesterase InhibitorsNeuroprotective AgentsOxidopamineReactive Oxygen SpeciesThiazolesacetylcholinesterase inhibitorsAlzheimer’s diseaseDrosophilaneurodegenerative diseasesneuroprotectionoxidative stressSH-SY5Y cellsthiazol

Identifiers

PMID42589300
PMCPMC13465329

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.