ArticleInternational journal of molecular sciences2026
Transcriptomic Analysis Reveals PACS1 as a Potential Shared Candidate Biomarker for Apical Periodontitis and Osteoporosis.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Apical periodontitis (AP), a localized inflammatory bone disease, and osteoporosis (OP), a systemic metabolic bone disorder, are both characterized by chronic inflammation and dysregulated bone metabolism, yet the molecular mechanisms underlying their association remain unclear. This study aimed to identify shared biomarkers and pathogenic pathways linking AP and OP. Gene expression datasets for AP and OP were obtained from the Gene Expression Omnibus database, and shared differentially expressed genes were identified and analyzed using functional enrichment, Gene set enrichment analysis (GSEA), Gene set variation analysis GSVA, and single-sample gene set enrichment analysis (ssGSEA)-based immune infiltration approaches. A random forest model was applied to prioritize candidate genes, followed by validation using single-cell RNA sequencing datasets, clinical samples, and in vitro assays. Forty-three shared differentially expressed genes were identified, among which
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